PMID: 6402418Mar 1, 1983Paper

Total parenteral nutrition in infancy: effect on the liver and suggested pathogenesis

Gut
C A HughesM J Harran

Abstract

Biochemical, histological, and electron-microscopic investigation of seven preterm infants who became jaundiced after prolonged total parenteral nutrition showed conjugated hyperbilirubinaemia apparently due to cholestasis without significant primary liver cell injury. In the absence of evidence indicating a direct toxic effect on the liver of this form of nutrition the necropsy findings in one child and analogy with the effects of total parenteral nutrition in animals suggest that the cholestasis is the result of suppression of trophic and/or secretion-stimulating hormone(s) normally produced by the gut, due to absent enteral nutrition. Biochemical and electron-microscopic findings suggest that liver cell damage occurs after resumption of enteral nutrition.

References

Jan 1, 1979·Schizophrenia Bulletin·S CantorR Postuma
Mar 1, 1979·Journal of Toxicology and Environmental Health·K Lapis, J V Johannessen
Mar 1, 1977·The Journal of Pediatrics·J BernsteinK P Heidelberger
Feb 1, 1975·The Journal of Pediatrics·R Rager, M J Finegold
Jun 1, 1975·Journal of Pediatric Surgery·R J Touloukian, J H Seashore
Feb 1, 1976·American Journal of Surgery·B M RodgersJ L Talbert
Jan 1, 1976·Biology of the Neonate·M A ZarifD Vidyasagar
Jul 1, 1972·The Journal of Pediatrics·J D JohnsonP Sunshine
Jan 1, 1973·Archives of Surgery·R J Touloukian, S E Downing
Jan 1, 1971·The Journal of Pediatrics·V H PedenM A Skelton
Sep 1, 1980·Archives of Disease in Childhood·A LucasA Aynsley-Green

❮ Previous
Next ❯

Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N MorikawaM Kitajima
Jul 15, 1987·Experientia·R A Goodlad, N A Wright
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M OshitaS Tashiro
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·M Angelico, P Della Guardia
Jan 1, 1985·Journal of the American College of Nutrition·T P Stein
Oct 1, 1988·Australian Paediatric Journal·W D FordG LeQuesne
May 3, 2006·Biological & Pharmaceutical Bulletin·Masuhiro NishimuraAiko Yamauchi
Mar 4, 2014·PloS One·Naho MorisakiUNKNOWN Neonatal Research Network of Japan
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J L Shaffer
Jun 1, 1990·Journal of Pediatric Surgery·A KubotaY Takagi
Jun 1, 1990·Journal of Pediatric Surgery·G F WhalenJ Folkman
Apr 1, 1985·The Journal of Surgical Research·H R FreundH S Bjornson
Jun 1, 1987·The Journal of Surgical Research·D L JacobsS R Petersen
Mar 1, 1984·The British Journal of Surgery·J B RaineyR C Williamson
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P F Whitington
Aug 1, 1985·The Journal of Pediatrics·K A DahlstromM E Ament
Nov 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·N HandaK Naito
May 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·A RiveraE Catarau
May 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S HataA Okada
Nov 9, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·V ColombC Ricour
Nov 1, 1985·International Ophthalmology·J VernotD Weinberg
Jul 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian P J AlwaynMark Puder
Mar 1, 1987·Medical Toxicology·H J Zimmerman, J H Lewis
Sep 22, 2006·The Journal of Nutrition·Hui WangBoris Yoffe
Aug 2, 2018·Journal of Medical Ultrasound·Takashi ImamuraMitsuaki Hosoya
Mar 18, 1999·Baillière's Clinical Gastroenterology·I W Booth, A D Lander
Mar 24, 2021·The American Journal of Surgical Pathology·Sonja ChenSara O Vargas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.