PMID: 9002082Jan 1, 1997Paper

Total parenteral nutrition increases uptake of latex beads by Peyer's patches

JPEN. Journal of Parenteral and Enteral Nutrition
J KhanA Okada

Abstract

Dysfunction of the intestinal barrier, as evidenced by increased intestinal permeability and bacterial translocation, has been reported under total parenteral nutrition (TPN). However, the role of Peyer's patches on the intestinal barrier in TPN is not well understood. We investigated whether TPN alters the uptake of microparticles by the follicle-associated epithelium of Peyer's patches. Twenty rats were divided into two groups, a control group and a TPN group. Fluorescent polystyrene latex beads, 3.2 +/- 0.2 microns in diameter, were used as a probe for measuring the uptake by Peyer's patches. After 1 week of consuming either the control or TPN diet, rats were killed. On the day of killing, 0.1 mL of latex beads solution was injected into a 1-cm length of ileal loop, within 10 cm of the ileocecal valve. Samples were taken after 30 minutes of injection, sectioned by cryostat, and then viewed under a fluorescent microscope. Follicle-associated epithelial length and particles were counted using a confocal laser scanning microscope. The number of particles within each compartment was standardized per unit length of epithelium of Peyer's patches. Particle numbers within Peyer's patch dome of the TPN group were significantly increa...Continue Reading

References

Jun 1, 1974·European Journal of Immunology·D Guy-GrandP Vassalli
Jul 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·Y IiboshiA Okada
Nov 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·A L BuchmanS R Vijayaroghavan

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Citations

Aug 8, 2001·Advanced Drug Delivery Reviews·M A ClarkB H Hirst
Aug 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joshua J ReinekeEdith Mathiowitz
Dec 19, 2014·The Cochrane Database of Systematic Reviews·Katharine AbbaYemisi Takwoingi
Jul 8, 2011·The Cochrane Database of Systematic Reviews·Katharine AbbaPaul Garner
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·G Minard, K A Kudsk
Jun 14, 2006·Cirugía española·Aomar Abdel-Lah MohamedAlberto Gómez Alonso

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