Total phenolic and flavonoid contents and antihypertensive effect of the crude extract and fractions of Calamintha vulgaris

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Shamim KhanAbdul Jabbar Shah

Abstract

Calamintha vulgaris L., has been used medicinally in the management hypertension. To investigate the antihypertensive mechanisms of extract of C. vulgaris L., in Sprague-Dawley (SD) rat. Total phenol and total flavonoid contents were determined in the crude extract through HPLC. In vivo and in vitro pharmacological approaches were utilized to test the crude extract and fractions of C. vulgaris in Sprague-Dawley (SD) rats. The effect on mean arterial pressure (MAP) was compared in normotensive and high salt-induced hypertensive rats. Crude extract and nHexane, chloroform, ethylacetate and aqueous fractions of C. vulgaris were tested. In vitro experiments were carried out in isolated rat and rabbit aortae, to probe vascular mechanism(s). Extract was also evaluated for acute toxicity study in mice. Crude extract and fractions of C. vulgaris induced a fall in MAP in normotensive and high salt-induced hypertensive rats at different doses. The effect was more significant in the hypertensive rats (Max. fall, 38.67 ± 2.17 vs 44.16 ± 4.67 mmHg). Among the fractions, chloroform was more effective (Max. fall, 53.20 ± 1.23 mmHg) and aqueous the least (Max. fall, 38.66 ± 1.12 mmHg). Normotensive rats pretreated with atropine (2 mg/kg) or L-...Continue Reading

Citations

Sep 17, 2019·Clinical and Experimental Hypertension : CHE·Taseer AhmadAbdul Jabbar Shah
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahMariusz Jaremko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.