Total replacement of the mitral apparatus with a stentless, chordally supported mitral valve allograft: an experimental study

The Journal of Thoracic and Cardiovascular Surgery
H O VetterB Reichart

Abstract

Mitral valves, including the papillary muscles, were harvested from freshly slaughtered sheep and implanted in 10 recipient growing sheep. A strip of ovine pericardium was used to reinforce the anulus and a patch of expanded polytetrafluoroethylene was used to cover the donor papillary muscle. In four valves the natural chordae tendineae at the anterior cusp were supported by two pairs of 5-0 expanded polytetrafluoroethylene sutures. At the beginning of the experiment two animals died early of valve incompetence. Another animal had to be put to death because of paraplegia after extracorporeal circulation and one died on postoperative day 41 of endocarditis. Six sheep were electively put to death, five after 153 +/- 8 days and one after 43 days. At the time of follow-up, a complete hemodynamic study including echocardiography and stress testing was performed. Heart rate at rest was 91 +/- 14 beats/min, left ventricular systolic pressure 96 +/- 20 mm Hg, left ventricular end-diastolic pressure 11 +/- 5 mm Hg, cardiac output 2.04 +/- 0.40 L/min, and the mean transvalvular pressure gradient was 4.9 +/- 2.8 mm Hg as measured by cardiac catheterization. Echocardiography showed excellent movement of all valve components. However, mino...Continue Reading

References

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Citations

Aug 6, 1998·The Annals of Thoracic Surgery·V M ReddyF L Hanley
Aug 4, 2001·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·Mark D. PlunkettDale M. Geiss
Feb 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·M KomedaD C Miller
Aug 30, 2000·The Journal of Thoracic and Cardiovascular Surgery·A S KumarP Chopra

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