Total saponin extract, ginsenoside Rb1, and compound K alleviate peripheral and central neuropathic pain through estrogen receptors on rats.

Phytotherapy Research : PTR
Jee Youn LeeTae Young Yune

Abstract

In this study, we investigated whether total saponin extract (TSE), ginsenoside Rb1, and Rb1 metabolite compound K, which are isolated from red ginseng, have antinociceptive effects on peripheral and central neuropathic pain (PNP and CNP, respectively). PNP and CNP were induced by tail nerve injury (TNI) at S1 and by contusive spinal cord injury (SCI) at T9 in male Sprague-Dawley rats, respectively. Two weeks after TNI or 4 weeks after SCI, pain-induced rats were orally administered vehicle, TSE (50 mg/kg), Rb1 (12.5 mg/kg), compound K (7 mg/kg), or gabapentin (GBP, 60 mg/kg), and the antinociceptive effects were examined by von Frey filament, cold/warm water, and hot plate analyses. Allodynia and hyperalgesia were significantly alleviated by TSE, Rb1, and GBP 1 hr after drug administration. The immunohistochemistry and real-time RT-PCR results showed that the activation of microglia/astrocytes and the expression of inflammatory mediators such as Il-1β, Il-6, iNOS, and Cox-2 were also significantly inhibited in L4-L5 spinal cord of CNP-induced rats 1 hr after drug administration. Furthermore, the antinociceptive effects of TSE and Rb1 were reversed by treatment with the estrogen receptor (ER) antagonist ICI182780. In particular...Continue Reading

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Sep 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A DeLeoA Malhotra
Aug 1, 1997·Journal of Neurotrauma·M D Christensen, C E Hulsebosch
Jan 5, 2001·Journal of Natural Products·W Y KimJ H Park
Jan 6, 2001·Biological & Pharmaceutical Bulletin·E A BaeD H Kim
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·YoungJoo LeeSeungKi Lee
Sep 30, 2004·Science's STKE : Signal Transduction Knowledge Environment·Ru-Rong Ji, Gary Strichartz
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Koichi ObataKoichi Noguchi
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Eun-Ah BaeDong-Hyun Kim
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C Hains, Stephen G Waxman
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peng ZhaoBryan C Hains
Oct 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Wai-Sum LauMan-Sau Wong
Jun 19, 2008·European Journal of Pharmacology·Fabrice PiuMark R Brann
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong-Jing GaoRu-Rong Ji
Dec 31, 2011·The Journal of Pharmacology and Experimental Therapeutics·Jin-Sun ParkHee-Sun Kim
Feb 5, 2013·Pain·Nanna Brix Finnerup
Mar 19, 2013·European Journal of Pharmacology·Joanna MikaBarbara Przewlocka
Jun 26, 2013·British Journal of Anaesthesia·A Ellis, D L H Bennett

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