PMID: 25743800Mar 7, 2015Paper

Total serum bile acid as a potential marker for the diagnosis of cholangiocarcinoma without jaundice

Asian Pacific Journal of Cancer Prevention : APJCP
Sutthikan SombattheeraSiriporn Proungvitaya

Abstract

Diagnosis of cholangiocarcinoma (CCA) is difficult when patients do not show jaundice. The aim of this study was to examine the feasibility of using the total serum bile acid (TSBA) level as an aid for the diagnosis of CCA in patients without jaundice. For this purpose, TSBA of the following groups were measured using a Beckman Synchron CX4 clinical chemistry analyzer: 60 cases of CCA with total serum bilirubin ≤2 mg/dL (low total bilirubin group, LTB); 32 cases of CCA with total serum bilirubin >2 mg/dL (high total bilirubin group, HTB); and 115 healthy controls. Liver function parameters such as serum cholesterol, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were also examined. The results showed that the TSBA of both LTB and HTB groups of the CCA patients were significantly higher than that of the healthy controls. Also, significant correlation was observed between TSBA and total bilirubin levels in the HTB group of CCA patients. However, no such correlation was seen in the LTB group. The cut-off value of TSBA was determined for the LTB group of CCA patients using the receiver operating characteristic curve analysis, and it was 6.05 μmol/L with the sensitivity and s...Continue Reading

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Citations

Oct 17, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jesus M BanalesRocio I R Macias
Jun 13, 2019·Oncology Letters·Surangkana SanmaiSiriporn Proungvitaya
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Elisa ManieriGuadalupe Sabio
Jun 24, 2021·Asia-Pacific Journal of Clinical Oncology·Wei WangYu-Liang Li

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