Total small vessel disease score and functional outcomes following acute intracerebral hemorrhage

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Yoko KimuraTsutomu Sasaki

Abstract

Individual cerebral small vessel disease (SVD) markers are independent predictors for poor prognosis following intracerebral hemorrhage (ICH), however, the impact of the cumulative SVD burden on outcomes remains unclear. We aimed to investigate the association between the global SVD burden and functional outcomes following ICH. We retrospectively evaluated a consecutive cohort of patients with ICH who underwent brain magnetic resonance imaging and magnetic resonance angiography, from a prospective registry. We identified the presence and severity of the SVD markers (cerebral microbleeds, lacunar infarctions, periventricular hyperintensities, and deep white matter hyperintensities) and summed them to obtain the modified total SVD score (0-4). Poor functional outcomes were defined as a modified Rankin Scale score at discharge ≥ 3. A multivariate logistic regression model was used to assess the association between patient outcomes and the SVD score. A total of 144 patients were included (65.0 ± 12.2 years, 67.4% male). The modified total SVD score was potentially associated with poor functional outcomes (odds ratio [OR] 1.72, 95% confidence interval [CI] 0.97-3.03) after adjustment for age, sex, history of stroke, chronic kidney d...Continue Reading

Citations

Nov 5, 2020·Annals of Neurology·Mark A RodriguesUNKNOWN Lothian Audit of the Treatment of Cerebral Haemorrhage Collaborators
Feb 9, 2021·Journal of Atherosclerosis and Thrombosis·Tianqi XuYi Fu

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