Total small vessel disease score and risk of recurrent stroke: Validation in 2 large cohorts.

Neurology
Kui Kai LauPeter M Rothwell

Abstract

In patients with TIA and ischemic stroke, we validated the total small vessel disease (SVD) score by determining its prognostic value for recurrent stroke. Two independent prospective studies were conducted, one comprising predominantly Caucasian patients with TIA/ischemic stroke (Oxford Vascular Study [OXVASC]) and one predominantly Chinese patients with ischemic stroke (University of Hong Kong [HKU]). Cerebral MRI was performed and assessed for lacunes, microbleeds, white matter hyperintensities (WMH), and perivascular spaces (PVS). Predictive value of total SVD score for risk of recurrent stroke was determined and potential refinements considered. In 2,002 patients with TIA/ischemic stroke (OXVASC n = 1,028, HKU n = 974, 6,924 patient-years follow-up), a higher score was associated with an increased risk of recurrent ischemic stroke (adjusted hazard ratio [HR] per unit increase: 1.32, 1.16-1.51, p < 0.0001; c statistic 0.61, 0.56-0.65, p < 0.0001) and intracerebral hemorrhage (ICH) (HR 1.54, 1.11-2.13, p = 0.009; c statistic 0.65, 0.54-0.76, p = 0.006). A higher score predicted recurrent stroke in SVD and non-SVD TIA/ischemic stroke subtypes (c statistic 0.67, 0.59-0.74, p < 0.0001 and 0.60, 0.55-0.65, p < 0.0001). Including...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jan 24, 2009·Lancet Neurology·Steven M GreenbergUNKNOWN Microbleed Study Group
Apr 5, 2013·Neurology·Sergi Martinez-RamirezAnand Viswanathan
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Nov 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordDavid J Werring
Aug 29, 2014·Neurology·Glen C Jickling, Christopher Chen
Jul 21, 2015·Neurobiology of Aging·Julie StaalsJoanna M Wardlaw
Mar 20, 2016·Cellular and Molecular Neurobiology·Joel RamirezSandra E Black

❮ Previous
Next ❯

Citations

Jul 4, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Kui Kai LauPeter M Rothwell
Sep 11, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marilyn J CipollaSiu-Lung Chan
Dec 9, 2017·Journal of the American Heart Association·Kui Kai LauHenry Ka Fung Mak
Dec 21, 2018·Stroke; a Journal of Cerebral Circulation·Pinar YilmazMeike W Vernooij
Mar 5, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xueyun LiuQi Fang
Feb 12, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·X-H XuF Gao
Apr 18, 2019·Journal of Stroke·Alvin S DasAnand Viswanathan
Oct 9, 2019·Brain Sciences·Larisa A DobryninaLyudmila A Kalashnikova
Feb 17, 2019·Neurology·Marios K GeorgakisMartin Dichgans
Jun 12, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Megumi HaraHideo Hara
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Kui Kai LauUNKNOWN Oxford Vascular Study
May 1, 2019·Stroke; a Journal of Cerebral Circulation·Omer Faruk EkerNorbert Nighoghossian
Feb 23, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Kohei SuzuyamaHideo Hara
May 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Huimin ChenTao Feng
May 12, 2018·Scientific Reports·Xiaopei XuEdward S Hui
Sep 5, 2019·Journal of Geriatric Psychiatry and Neurology·Yan LiangWai-Kwong Tang
May 21, 2020·Frontiers in Aging Neuroscience·Akihiro ShindoHidekazu Tomimoto
Dec 20, 2019·Journal of Neurology·Marco PasiAneesh B Singhal
May 16, 2018·Stroke; a Journal of Cerebral Circulation·Xueqiu Jian, Myriam Fornage
Sep 17, 2020·Neurology·Jonathan G BestUNKNOWN Clinical Relevance of Microbleeds in Stroke (CROMIS-2) collaborators
Dec 8, 2020·Stroke; a Journal of Cerebral Circulation·Houwei DuUNKNOWN Clinical Relevance of Microbleeds in Stroke (CROMIS-2) Collaborators
Oct 7, 2020·Stroke; a Journal of Cerebral Circulation·Lily W ZhouThalia S Field
Dec 15, 2020·Translational Neuroscience·Pan WangYuying Zhou

❮ Previous
Next ❯

Software Mentioned

SPSS
OXVASC

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.