PMID: 16522909Mar 9, 2006Paper

Total sulfur amino acid requirement of healthy school-age children as determined by indicator amino acid oxidation technique

The American Journal of Clinical Nutrition
Justine M TurnerPaul B Pencharz

Abstract

Current total sulfur amino acid (TSAA) requirements of children are based on a factorial estimate that involves several assumptions. The objective was to determine the TSAA requirement (methionine alone) of healthy school-age children by measuring the appearance of 13CO2 (F13CO2) in breath after the oxidation of l-[1-13C]phenylalanine in response to graded methionine intakes. Six healthy school-age children randomly received each of 6 methionine intakes (0, 5, 10, 15, 25, and 35 mg.kg(-1).d(-1)) along with an amino acid mixture to give a final protein intake of 1.5 g.kg(-1).d(-1) and an energy intake of 1.7 x resting energy expenditure. The diet was devoid of cysteine. The mean TSAA requirement was determined by applying a biphase linear regression crossover analysis on F13CO2 data, which identified a breakpoint at minimal F13CO2 in response to graded methionine intakes. The mean and population-safe (upper 95% CI) intakes of TSAA (as methionine) were determined to be 12.9 and 17.2 mg.kg(-1).d(-1), respectively. The current study suggests that children of this age group have a mean TSAA requirement similar to that of adults (12.6 mg.kg(-1).d(-1)). Therefore, it is valid to use a factorial approach, which assumes that maintenance...Continue Reading

References

Jan 1, 1987·Methods in Enzymology·O W Griffith
Jan 1, 1986·Annual Review of Nutrition·M H Stipanuk
Oct 1, 1973·Nutrition Reviews·G B Forbes
Jun 1, 1974·The Journal of Nutrition·T S AguilarA E Harper
Jun 24, 2000·Annals of the New York Academy of Sciences·K J EllisW W Wong
Nov 28, 2001·The American Journal of Clinical Nutrition·M Di BuonoP B Pencharz
Mar 11, 2003·Annual Review of Nutrition·Paul B Pencharz, Ronald O Ball
Apr 30, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Jan 10, 1958·The Journal of Nutrition·M S REYNOLDSC A BAUMANN

❮ Previous
Next ❯

Citations

Dec 6, 2008·The American Journal of Clinical Nutrition·Karen P ChapmanPaul B Pencharz
Feb 7, 2012·Antioxidants & Redox Signaling·Anne M FitzpatrickLou Ann S Brown
Nov 10, 2006·The American Journal of Clinical Nutrition·Mohammad A HumayunPaul B Pencharz
Feb 27, 2009·The American Journal of Clinical Nutrition·Sandra C van CalcarDenise M Ney
Aug 13, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Anura V Kurpad, Tinku Thomas
Oct 31, 2012·The British Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Nov 4, 2011·The American Journal of Clinical Nutrition·Rajavel ElangoPaul B Pencharz
Apr 18, 2015·BMC Pregnancy and Childbirth·Paul Anthony DawsonHarold David McIntyre
Sep 1, 2007·Journal of Breath Research·Anil S Modak
Jan 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Diana R MagerPaul B Pencharz
Aug 9, 2007·The American Journal of Clinical Nutrition·Rajavel ElangoPaul B Pencharz
Dec 24, 2010·Pediatric Research·Jean W HsuWilliam C Heird
Mar 1, 2012·Nutrition Reviews·Glenda Courtney-MartinPaul B Pencharz
Jun 9, 2015·Journal of Nutritional Science and Vitaminology·Aki OgawaYasuhiro Kido
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Rajavel ElangoPaul B Pencharz
Oct 9, 2007·The American Journal of Clinical Nutrition·Mohammad A HumayunPaul B Pencharz
Oct 31, 2012·The British Journal of Nutrition·Raja R Pillai, Anura V Kurpad
Jul 11, 2008·The American Journal of Clinical Nutrition·Glenda Courtney-MartinPaul B Pencharz
Feb 15, 2013·Pediatric Research·Femke de GroofJohannes B van Goudoever
Jan 22, 2008·The Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Mar 23, 2011·Seminars in Cell & Developmental Biology·Paul A Dawson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.