Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer

Chimia
Sarah Saint-AuretNicolas Blanchard

Abstract

Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.

Citations

Jul 29, 2018·Biology of the Cell·Caroline Demangel, Stephen High
Feb 20, 2021·Immunological Reviews·Caroline Demangel

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