Total synthesis and structural revision of mycalol, an anticancer natural product from the marine source

Organic Letters
B SeetharamsinghD Srinivasa Reddy

Abstract

The total synthesis of an anticancer (anaplastic thyroid) natural lipid mycalol has been accomplished for the first time. Synthesis of originally proposed structure necessitated the revision of structure in which the position of acetate group moved from C20 to C19 and a change in stereochemistry of the glycerol unit.

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Citations

Jan 27, 2016·The Journal of Organic Chemistry·Guido F PauliJ Brent Friesen
May 21, 2015·The Journal of Organic Chemistry·Subhendu DasRajib Kumar Goswami
Feb 6, 2019·Organic & Biomolecular Chemistry·Masao MoritaYuichi Kobayashi

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