Total synthesis of (-)-dictyostatin

Journal of the American Chemical Society
Gregory W O'Neil, Andrew J Phillips

Abstract

A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.

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