Total Synthesis of (±)-Gracilioether F

Organic Letters
Xin-Yue ShenHenry N C Wong

Abstract

Total synthesis of (±)-gracilioether F was achieved via a pivotal reductive cleavage of 1,2-dioxane from allenic ester in 11 steps. The key 1,2-dioxane species, derived from singlet oxygen and a diene, could be used as a common precursor for a stereocontrolled formation of the crucial 1,4-diol through a reductive cleavage.

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Citations

Jun 22, 2017·The Journal of Organic Chemistry·Ritabrata Datta, Subrata Ghosh

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