Total Synthesis of (+)-Rubriflordilactone A.

Angewandte Chemie
Shermin S GohEdward A Anderson

Abstract

Two enantioselective total syntheses of the nortriterpenoid natural product rubriflordilactone A are described, which use palladium- or cobalt-catalyzed cyclizations to form the CDE rings, and converge on a late-stage synthetic intermediate. These key processes are set up through the convergent coupling of a common diyne component with appropriate AB-ring aldehydes, a strategy that sets the stage for the synthetic exploration of other members of this family of natural products.

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Citations

Sep 24, 2015·Journal of the American Chemical Society·Jian LiAng Li
Mar 16, 2017·Chemical Reviews·Zachary G BrillThomas J Maimone
Apr 20, 2017·Journal of the American Chemical Society·Elizabeth J RaymentEdward A Anderson
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Oct 16, 2018·Angewandte Chemie·Binjie MaHanfeng Ding
Oct 9, 2019·Angewandte Chemie·Mujahid MohammadEdward A Anderson
Aug 25, 2016·Chemistry : a European Journal·Bastian MildeDaniel B Werz
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Apr 29, 2016·Angewandte Chemie·Peng YangAng Li
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Oct 7, 2021·Chemistry : a European Journal·Finn J GeffersDaniel B Werz

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