Total synthesis of avermectin B1a revisited

The Journal of Antibiotics
Shuji YamashitaMasahiro Hirama

Abstract

Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by Ōmura and co-workers. Owing to their potent anthelmintic and insecticidal activities, as well as their unique pentacyclic architecture, the avermectin family attracted keen interest from synthetic organic chemists. We have recently completed a more efficient and straightforward total synthesis of avermectin B1a, as compared with previous syntheses.

References

Mar 1, 1979·Antimicrobial Agents and Chemotherapy·R W BurgS Omura
Aug 26, 1983·Science·W C CampbellT A Jacob
Oct 1, 1980·Journal of Medicinal Chemistry·J C ChabalaD A Ostlind
Oct 8, 2005·Organic & Biomolecular Chemistry·Simon BaileyEric J Thomas
Oct 24, 2007·Carbohydrate Research·Shannon C Timmons, David L Jakeman
Nov 27, 2007·International Journal of Antimicrobial Agents·S Omura

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Citations

Oct 12, 2016·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masahiro Hirama
Jul 10, 2021·Journal of Medicinal Chemistry·Lovepreet Singh, Kamaljit Singh
Jun 29, 2018·Chemical Reviews·Clay S Bennett, M Carmen Galan

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

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