Total Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid

The Journal of Organic Chemistry
James T WilliamsRichard J Payne

Abstract

The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are functional components of flagellin and pili proteins within clinically relevant Gram-negative bacteria. Herein, we describe the total synthesis of the most common pseudaminic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid. The divergent nature of the route reported here provides a robust and versatile means to access other members of the family, together with analogues, for probing the functional role of the pseudaminic acids and pseudaminic acid derived proteins in the future.

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Jan 17, 2020·Chembiochem : a European Journal of Chemical Biology·Emily K P FlackMartin A Fascione
Jul 17, 2018·Chemical Reviews·Liuqing WenPeng George Wang
Aug 25, 2017·Journal of the American Chemical Society·Han LiuXuechen Li
Oct 29, 2019·The Journal of Organic Chemistry·Jack Everson, Milton J Kiefel

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