Total thyroid ablation in Graves' orbitopathy

Journal of Endocrinological Investigation
Francesca MenconiM Marinò

Abstract

Graves' orbitopathy (GO) is an autoimmune condition almost always associated with autoimmune thyroid disease, especially Graves' disease (GD). According to the most widely accepted model, the autoantigens responsible for GO would include molecules expressed by thyroid epithelial cells that are present also in orbital tissues. The high likelihood that the etiologies of GO and of the underlying autoimmune thyroid diseases are somehow linked is confirmed by the very close relationship between GO, the onset and the course of Graves' diseases, the size of the thyroid gland, and most importantly, thyroid function and thyroid treatment. Based on these considerations, it has been proposed that complete removal of thyroid antigens and of thyroid infiltrating lymphocytes, the so-called total thyroid ablation (TTA), may be followed by an attenuation of the immune reaction against orbital antigens, and ultimately by an amelioration of GO. The possibility that TTA, achieved by near total thyroidectomy followed by radioiodine, may be beneficial for GO was initially suggested by two retrospective studies and more recently by two prospective, randomized clinical trials conducted in patients with moderate GO treated with intravenous glucocortic...Continue Reading

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Citations

Feb 18, 2016·Journal of Endocrinological Investigation·M RiedlG J Kahaly
May 22, 2016·Journal of Endocrinological Investigation·M MoletiF Vermiglio
Jun 20, 2016·Journal of Endocrinological Investigation·L BartalenaP Vitti
Oct 7, 2016·Endocrine·Francesca MenconiMichele Marinò
Jan 18, 2018·Thyroid : Official Journal of the American Thyroid Association·Elena SabiniMichele Marinò
May 2, 2018·JAMA Ophthalmology·Giovanna Rotondo DottoreMichele Marinò
Jun 23, 2018·Ophthalmic Plastic and Reconstructive Surgery·Michele MarinòClaudio Marcocci
May 21, 2020·Clinical Nuclear Medicine·Shahrara AriamaneshSeyed Rasoul Zakavi
Mar 30, 2018·European Thyroid Journal·Elena SabiniMichele Marinò
Jun 21, 2018·Journal of Endocrinological Investigation·G LanzollaM Marinò
Feb 11, 2020·Frontiers in Endocrinology·Giulia LanzollaMichele Marinò
Feb 20, 2021·Current Opinion in Ophthalmology·Alon Kahana
Apr 13, 2021·Journal of Endocrinological Investigation·Giulia LanzollaMichele Marinò

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