Total tumor volume predicts survival following liver resection in patients with hepatocellular carcinoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mu-Xing LiJian-Qiang Cai

Abstract

Assessing the prognosis of patients with hepatocellular carcinoma (HCC) by the number and size of tumors is sometimes difficult. The main purpose of the study was to evaluate the prognostic value of total tumor volume (TTV), which combines the two factors, in patients with HCC who underwent liver resection. We retrospectively reviewed 521 HCC patients from January 2001 to December 2008 in our center. Patients were categorized using the tertiles of TTV. The prognostic value of TTV was assessed. With a median follow-up of 116 months, the 1-, 3-, and 5-year overall survival (OS) rates of the patients were 93.1 , 69.9, and 46.3 %, respectively. OS was significantly differed by TTV tertile groups, and higher TTV was associated with shorter OS (P < 0.001). Multivariate analysis revealed that TTV was an independent prognostic factor for OS. Larger TTV was significantly associated with higher alpha-fetoprotein level, presence of macrovascular invasion, multiple tumor lesions, larger tumor size, and advanced tumor stages (all P < 0.05). Within the first and second tertiles of TTV (TTV ≤ 73.5 cm(3)), no significant differences in OS were detected in patients within and beyond Milan criteria (P = 0.183). TTV-based Cancer of the Liver Ital...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
May 15, 1997·Statistics in Medicine·D W HosmerS Lemeshow
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Mar 29, 2000·Journal of Mathematical Psychology·M R Forster
Sep 19, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Llovet, J Bruix
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
May 26, 2005·Annals of Surgical Oncology·Kelvin K NgUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christian TosoNorman M Kneteman
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 10, 2010·Journal of Surgical Oncology·Atsushi NanashimaTakeshi Nagayasu
Dec 9, 2010·The Oncologist·Jorge A MarreroJean-Pierre Bronowicki
Jul 16, 2011·Journal of Hepatology·Valentina SantiFranco Trevisani
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sean F AltekruseDavid E Kleiner
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
Nov 29, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yun-Hsuan LeeTeh-Ia Huo
Jun 5, 2014·Journal of Surgical Oncology·Annabelle L Fonseca, Charles H Cha
Nov 5, 2014·Seminars in Liver Disease·Vincenzo MazzaferroPietro Majno
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 18, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian TosoNorman M Kneteman
Jul 7, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Catherine de MartelSilvia Franceschi
Aug 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amit G Singal, Hashem B El-Serag
Sep 4, 2015·Journal of Gastroenterology and Hepatology·Young Kul JungSoon Ho Um

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Atsushi NanashimaTakeshi Nagayasu
Zhonghua wai ke za zhi [Chinese journal of surgery]
Wen-He ZhaoBao-Shan Fang
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Tao LvMingqing Xu
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
R ParasoleB Daniele
© 2022 Meta ULC. All rights reserved