Total tumour diameter is superior to unifocal diameter as a predictor of papillary thyroid microcarcinoma prognosis

Scientific Reports
Chunping LiuTao Huang

Abstract

The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE), local infiltration, central lymph node metastasis (LNM), and prognosis. Consecutive patients (n = 1102) were identified and the proportions of LNM, ETE, and local infiltration were similar between PTCs with a unifocal tumour diameter >1 cm and ≤2 cm and PTMCs with a multifocal TTD >1 cm and ≤2 cm. The proportions of LNM, ETE, and local infiltration were also similar between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD ≤1 cm. However, when comparing PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm, significant differences were observed. In the Kaplan-Meier analysis, significant differences were observed between PTMCs with a unifocal diameter ≤1 cm vs. multifocal TTD >1 cm and multifocal TTD ≤1 cm vs. multifocal TTD >1 cm. Accordingly, TTD may represent a more accurate criterion for tumour size of PTCs and should be considered in the revised AJCC staging system.

References

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Citations

Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Amanda Doubleday, Rebecca S Sippel
Apr 25, 2019·Current Medical Science·Wei ShiChun-Ping Liu
Nov 22, 2019·Journal of Endocrinological Investigation·J-W FengZ Qu
Jul 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xuejun GaoXia Cai

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Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

SPSS

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