The nematode Caenorhabditis elegans was the first organism for which touch insensitive mutants were obtained. The study of the genes defective in these mutants has led to the identification of components of a mechanosensory complex needed for specific cells to sense gentle touch to the body. Multiple approaches using genetics, cell biology, biochemistry, and electrophysiology have characterized a channel complex, containing two DEG/ENaC pore-forming subunits and several other proteins, that transduces the touch response. Other mechanical responses, sensed by other cells using a variety of other components, are less well understood in C. elegans. Many of these other senses may use TRP channels, although DEG/ENaC channels have also been implicated.
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
A developmental analysis of spontaneous and reflexive reversals in the nematode Caenorhabditis elegans
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mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
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A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
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Model organisms: new insights into ion channel and transporter function. Stomatin homologues interact in Caenorhabditis elegans
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Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons
In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system
MEC-2 is recruited to the putative mechanosensory complex in C. elegans touch receptor neurons through its stomatin-like domain
Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons
The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
Decreased sensory stimulation reduces behavioral responding, retards development, and alters neuronal connectivity in Caenorhabditis elegans
Temperature-sensitive mutant of the Caenorhabditis elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance
Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons
A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog
Functional phenotypic rescue of Caenorhabditis elegans neuroligin-deficient mutants by the human and rat NLGN1 genes
mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development
Dicalcin, a zona pellucida protein that regulates fertilization competence of the egg coat in Xenopus laevis
Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants
C. elegans TRP family protein TRP-4 is a pore-forming subunit of a native mechanotransduction channel
Lateral facilitation between primary mechanosensory neurons controls nose touch perception in C. elegans
The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation
Epigenetic effect of testosterone in the behavior of C. elegans. A clue to explain androgen-dependent autistic traits?
An image-free opto-mechanical system for creating virtual environments and imaging neuronal activity in freely moving Caenorhabditis elegans
The C-terminal binding protein (CTBP-1) regulates dorsal SMD axonal morphology in Caenorhabditis elegans
Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans
Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans
let-7 miRNA controls CED-7 homotypic adhesion and EFF-1-mediated axonal self-fusion to restore touch sensation following injury
Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole
Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference
Steroids originating from bacterial bile acid degradation affect Caenorhabditis elegans and indicate potential risks for the fauna of manured soils
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