touché Is required for touch-evoked generator potentials within vertebrate sensory neurons.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sean E LowLouis Saint-Amant

Abstract

The process by which light touch in vertebrates is transformed into an electrical response in cutaneous mechanosensitive neurons is a largely unresolved question. To address this question we undertook a forward genetic screen in zebrafish (Danio rerio) to identify mutants exhibiting abnormal touch-evoked behaviors, despite the presence of sensory neurons and peripheral neurites. One family, subsequently named touché, was found to harbor a recessive mutation which produced offspring that were unresponsive to light touch, but responded to a variety of other sensory stimuli. The optogenetic activation of motor behaviors by touché mutant sensory neurons expressing channelrhodopsin-2 suggested that the synaptic output of sensory neurons was intact, consistent with a defect in sensory neuron activation. To explore sensory neuron activation we developed an in vivo preparation permitting the precise placement of a combined electrical and tactile stimulating probe upon eGFP-positive peripheral neurites. In wild-type larva electrical and tactile stimulation of peripheral neurites produced action potentials detectable within the cell body. In a subset of these sensory neurons an underlying generator potential could be observed in response...Continue Reading

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Citations

Apr 12, 2012·Journal of Neurophysiology·Sean E LowLouis Saint-Amant
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean E LowJohn Y Kuwada
Oct 20, 2010·The Journal of Cell Biology·Ellen A LumpkinAislyn M Nelson
Feb 1, 2011·Current Opinion in Genetics & Development·Erin G Reed-Geaghan, Stephen M Maricich
Jul 31, 2014·Genesis : the Journal of Genetics and Development·Bryan D CrawfordDave B Pilgrim
Dec 7, 2010·Progress in Neurobiology·Silke RinkwitzThomas S Becker
Jun 23, 2011·Annual Review of Neuroscience·Lief FennoKarl Deisseroth
Jan 3, 2014·Physiological Reviews·Emmanuel BourinetGerald W Zamponi
Sep 17, 2020·The Journal of Comparative Neurology·Hilary R KatzMelina E Hale
Oct 12, 2018·Cell Death Discovery·Suraiya Saleem, Rajaretinam Rajesh Kannan

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