Tourniquet compression: a non-invasive method to enhance nerve regeneration in nerve grafts

Neuroreport
Annika WiderbergLars B Dahlin

Abstract

One hindlimb of a rat was subjected to tourniquet compression (150, 200 and 300 mmHg; 2 h). After 6 days a 10 mm sciatic or tibial nerve graft from the compressed limb was sutured to bridge a 3-4 mm gap in the sciatic nerve of the non-compressed limb. The distances of regenerating sensory axons were measured 6 days post surgery (tibial grafts, 8 days). Compression at 200 and 300 mmHg led to significantly longer regeneration distances than those seen in controls. Incorporation of BrdU and expression of p75 receptor by non-neuronal cells (Schwann cells) in sciatic nerves 6 days after compression (150 and 300 mmHg; 2 h) was also increased as a sign of Schwann cell activation. Tourniquet compression may be used as a non-invasive method to enhance nerve regeneration in nerve grafts.

References

Jan 1, 1977·Scandinavian Journal of Plastic and Reconstructive Surgery·B Rydevik, G Lundborg
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·R A PedowitzB L Rydevik
Jul 1, 1991·The Journal of Surgical Research·W J Quiñones-BaldrichW S Moore
Jul 1, 1988·Trends in Neurosciences·E M JohnsonP S DiStefano
May 1, 1989·The Journal of Hand Surgery·A J Nitz, J J Dobner
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TaniuchiE M Johnson
Jul 1, 1973·Archives of Neurology·I G McQuarrie, B Grafstein
Jan 20, 1980·Brain Research·D S FormanD A Fuchs
Apr 9, 2001·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·T HaapaniemiL B Dahlin
Jul 27, 2001·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A WiderbergL B Dahlin
Dec 4, 2001·Cells, Tissues, Organs·T TömbölJ Hamar

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Citations

Jul 15, 2003·The International Journal of Neuroscience·Levent Sarikcioglu, Olcay Ozkan

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