PMID: 7059923Mar 1, 1982Paper

Tourniquet infusion versus hyperthermic perfusion

Cancer
C P KarakousisJ H Ewing

Abstract

The tourniquet infusion method was compared with hyperthermic perfusion in canine limbs by using Adriamycin, actinomycin-D, and melphalan. Tourniquet infusion provided comparable tissue levels with Adriamycin and significantly higher levels with actinomycin-D and melphalan in the treated extremity than hyperthermic perfusion with the same drugs and dosages. Higher systemic leak was observed, more so with melphalan, with the tourniquet infusion method. Tourniquet infusion has caused complete regression of four malignant tumors involving extremities (one malignant melanoma, two Kaposi's sarcomas, one squamous cell carcinoma) and partial greater than 50% regression of nine tumors (three malignant melanomas, three squamous cell carcinomas, one malignant schwannoma, one malignant fibrohistiocytoma, one liposarcoma) followed by excision of residual tumor. Five patients with extremity sarcomas precluding adequate surgical margins were treated preoperatively with the this method. Longer follow-up is needed, as is a larger number of patients for a valid comparison of tourniquet infusion with hyperthermic perfusion.

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Citations

Jul 15, 1999·Journal of Surgical Oncology·C P Karakousis, D L Driscoll
Apr 21, 1998·Seminars in Surgical Oncology·J F ThompsonC R Harman
Jan 1, 1985·The Japanese Journal of Surgery·I YokoyamaT Kondo
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Jan 1, 1985·Cancer Drug Delivery·C P KarakousisM Brecher
May 1, 1990·The Australian and New Zealand Journal of Surgery·D Bird, S Hart
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May 10, 2011·Current Problems in Surgery·Amira SankiJohn F Thompson
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Aug 30, 2008·Surgical Oncology Clinics of North America·Peter C A Kam, John F Thompson
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Aug 23, 2011·Journal of Surgical Oncology·Alessandro TestoriJohn F Thompson
Mar 1, 2002·American Journal of Surgery·Stefano GuadagniGianfranco Amicucci
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Oct 6, 1997·Annals of Surgical Oncology·C P KarakousisD L Driscoll

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