Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept.

Critical Care Medicine
Hector R WongLesley A Doughty

Abstract

To develop a clinically feasible stratification strategy for pediatric septic shock, using gene expression mosaics and a 100-gene signature representing the first 24 hrs of admission to the pediatric intensive care unit. Prospective, observational study involving microarray-based bioinformatics. Multiple pediatric intensive care units in the United States. Ninety-eight children with septic shock. None other than standard care. Patients were classified into three previously published, genome-wide, expression-based subclasses (subclasses A, B, and C) having clinically relevant phenotypic differences. The class-defining 100-gene signature was depicted for each individual patient, using mosaics generated by the Gene Expression Dynamics Inspector (GEDI). Composite mosaics were generated representing the average expression patterns for each of the three subclasses. Nine individual clinicians served as blinded evaluators. Each evaluator was shown the 98 individual patient mosaics and asked to classify each patient into one of the three subclasses, using the composite mosaics as the reference point. The respective sensitivities, specificities, positive predictive values, and negative predictive values of the subclassification strategy ...Continue Reading

References

Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Nov 25, 2003·Bioinformatics·Gabriel S EichlerDonald E Ingber
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
May 21, 2005·Physical Review Letters·Sui HuangDonald E Ingber
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kevin CamphausenPhilip J Tofilon
Mar 22, 2007·Physiological Genomics·Hector R WongUNKNOWN Genomics of Pediatric SIRS/Septic Shock Investigators
Jun 15, 2007·Journal of Intensive Care Medicine·James P Marcin, Murray M Pollack
Jan 4, 2008·Journal of Leukocyte Biology·John C Marshall
Mar 11, 2008·Nature Biotechnology·Paolo Fortina, Saul Surrey
May 31, 2008·American Journal of Respiratory and Critical Care Medicine·Hector R WongMark D Williams
Dec 11, 2008·Science Signaling·Igor F TsigelnySanjay K Nigam
Mar 28, 2009·Critical Care Medicine·Hector R WongUNKNOWN Genomics of Pediatric SIRS/Septic Shock Investigators
Jun 3, 2009·Critical Care Medicine·John C MarshallUNKNOWN International Sepsis Forum
Jun 13, 2009·Recent Patents on Inflammation & Allergy Drug Discovery·Derek S WheelerHector R Wong

❮ Previous
Next ❯

Citations

Jan 19, 2013·Pediatric Research·Hector R Wong
Jun 28, 2011·Critical Care Medicine·Hector R WongFrederick E Barr
Apr 19, 2012·Critical Care Medicine·Hector R Wong
Feb 18, 2012·World Journal for Pediatric & Congenital Heart Surgery·Derek S WheelerJoseph A Carcillo
Dec 16, 2011·Critical Care : the Official Journal of the Critical Care Forum·Michael J Hobson, Hector R Wong
Feb 10, 2012·Critical Care : the Official Journal of the Critical Care Forum·Hector R Wong
Nov 22, 2011·Critical Care : the Official Journal of the Critical Care Forum·Rajit K BasuHector R Wong
Feb 20, 2014·Trends in Molecular Medicine·David M Maslove, Hector R Wong
Aug 16, 2011·The Journal of Infection·Reetta Huttunen, Janne Aittoniemi
Jul 10, 2012·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Chin-Chen Wu
Mar 30, 2013·Critical Care Clinics·William Hanna, Hector R Wong
Nov 21, 2014·Critical Care : the Official Journal of the Critical Care Forum·Scott L WeissHector R Wong
Jan 28, 2014·The Lancet. Respiratory Medicine·Nuala J Meyer
Mar 2, 2017·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Katri V TyppoJacques Lacroix
Oct 16, 2015·World Journal for Pediatric & Congenital Heart Surgery·Kevin O MaherHector R Wong
Oct 11, 2017·Critical Care Medicine·Hector R WongChristopher J Lindsell
Feb 3, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Erin K StensonHector R Wong
Mar 29, 2019·Acta Anaesthesiologica Scandinavica·Steven Kwasi KorangJanus C Jakobsen
Jun 3, 2017·Pediatric Research·Pui-Ying Iroh Tam, Catherine M Bendel
Sep 13, 2019·Nature Reviews. Nephrology·Natalja L Stanski, Hector R Wong
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Derek S Wheeler, Hector R Wong
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Antigone Kotsaki, Evangelos J Giamarellos-Bourboulis
May 3, 2019·Journal of Clinical Microbiology·Ian L GunsolusNathan A Ledeboer
Jul 13, 2018·JCI Insight·J Brian McAlvinDaniel S Kohane
May 16, 2019·Current Opinion in Pediatrics·Mihir R Atreya, Hector R Wong
Aug 18, 2016·Expert Review of Anti-infective Therapy·Lauren Jacobs, Hector R Wong
Aug 23, 2019·The Journal of Critical Care Medicine·Alexandra LazărLeonard Azamfirei
Jan 26, 2012·Current Opinion in Pediatrics·Lakshmi Srinivasan, Mary C Harris
Jun 16, 2021·Pediatric Research·Hector R Wong
May 4, 2021·Critical Care Medicine·David M Maslove, J Kenneth Baillie
Jan 29, 2019·The Journal of Pediatrics·Tellen D BennettMichael G Kahn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Critical Care Medicine
Patrick D SolanHector R Wong
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Hector R WongThomas P Shanley
Physiological Genomics
Natalie Z CvijanovichGenomics of Pediatric SIRS/Septic Shock Investigators
© 2021 Meta ULC. All rights reserved