Toward a Cure: Does Host Immunity Play a Role?

MSphere
Jielin Zhang, Clyde S Crumpacker

Abstract

Three decades of research on human immunodeficiency virus (HIV) and AIDS reveal that the human body has developed through evolution a genome immune system embodying epigenetic regulation against pathogenic nucleic acid invasion. In HIV infection, this epigenetic regulation plays a cardinal role in HIV RNA production that silences HIV transcription at a molecular (RNA) level, controls viral load at a cellular (biological) level, and governs the viremic stage of AIDS at the clinical (patient) level. Even though the human genome is largely similar among humans and HIV is a single viral species, human hosts show significant differences in viral RNA levels, ranging from cell to organ to individual and expressed as elite controllers, posttreatment controllers, and patients with AIDS. These are signature biomarkers of typical epigenetic regulation whose importance has been shunted aside by interpreting all of AIDS pathogenesis by the known properties of innate and adaptive immunity. We propose that harnessing the host genome immune system, defined as epigenetic immunity, against HIV infection will lead toward a cure.

References

May 30, 1989·Biochemical and Biophysical Research Communications·M A Gama SosaR M Ruprecht
Mar 1, 1973·Journal of Theoretical Biology·R R Meyer
May 23, 2002·Science·Ronald H A Plasterk
Dec 17, 2004·Retrovirology·Shinya OmotoYoichi R Fujii
Feb 3, 2007·The Journal of Clinical Investigation·Jielin ZhangClyde S Crumpacker
Feb 26, 2013·Retrovirology·Thibault MesplèdeMark A Wainberg
Oct 24, 2013·Frontiers in Immunology·Jielin Zhang, Clyde Crumpacker
Oct 1, 2014·AIDS·Constanza MorénClàudia Fortuny
Jan 15, 2015·Annual Review of Medicine·Matthew S DahabiehEric Verdin
Jan 28, 2015·Molecular Therapy. Nucleic Acids·Kazuo SuzukiAnthony D Kelleher
Mar 4, 2015·Nature·Bruna MariniMarina Lusic
Aug 25, 2015·Stem Cells International·Jielin Zhang, Clyde Crumpacker
Feb 13, 2016·Trends in Immunology·Alexander Rölle, Petter Brodin
Mar 24, 2016·Current HIV/AIDS Reports·Eileen Scully, Galit Alter
Apr 10, 2016·Nucleic Acids Research·Marc S Weinberg, Kevin V Morris
Nov 4, 2016·Current Genetics·Agustina D'Urso, Jason H Brickner

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Citations

Dec 5, 2019·Brazilian Oral Research·Nely Cristina Medeiros CairesAntônio Paulino Ribeiro Sobrinho

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