PMID: 8942955Nov 26, 1996Paper

Toward a molecular definition of long-term memory storage

Proceedings of the National Academy of Sciences of the United States of America
C H BaileyE R Kandel

Abstract

The storage of long-term memory is associated with a cellular program of gene expression, altered protein synthesis, and the growth of new synaptic connections. Recent studies of a variety of memory processes, ranging in complexity from those produced by simple forms of implicit learning in invertebrates to those produced by more complex forms of explicit learning in mammals, suggest that part of the molecular switch required for consolidation of long-term memory is the activation of a cAMP-inducible cascade of genes and the recruitment of cAMP response element binding protein-related transcription factors. This conservation of steps in the mechanisms for learning-related synaptic plasticity suggests the possibility of a molecular biology of cognition.

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B A KarpinskiJ M Leiden
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J O'DellO Arancio
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P J BergoldJ H Schwartz
Aug 23, 1990·Nature·J M Bekkers, C F Stevens
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C H Bailey, M Chen
Dec 22, 1989·Science·J L SonnenbergT Curran
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·J L Burchfiel, C D Applegate
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·M DragunowK Jansen
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C H Bailey, M Chen
Nov 1, 1984·Psychological Bulletin·H P Davis, L R Squire
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M Klein, E R Kandel
Oct 7, 1994·Cell·T TullyM Del Vecchio

❮ Previous
Next ❯

Citations

Nov 15, 2000·Hippocampus·C Rampon, J Z Tsien
Aug 26, 1998·Annals of Neurology·B H Dobkin
Jul 20, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Roman, R L Davis
Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E B Keverne
Mar 4, 2005·Hippocampus·Lesley A Schimanski, Peter V Nguyen
Mar 14, 2002·Journal of Neuroscience Research·David A MatzilevichPramod K Dash
Aug 27, 2009·Experimental Brain Research·Karine FortinLaurent J Bouyer
Feb 19, 2013·Pflügers Archiv : European journal of physiology·Taofei Yin, Yi I Wu
Feb 17, 2005·Journal of Computational Neuroscience·David B PettigrewJohn H Byrne
Jun 23, 2009·Science and Engineering Ethics·Nick Bostrom, Anders Sandberg
Nov 19, 2003·Biochemical and Biophysical Research Communications·Rachel D GrothPaul G Mermelstein
Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marialaura AmadioAlessia Pascale
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Feb 1, 2000·Trends in Neurosciences·T R Soderling, V A Derkach
Mar 20, 2003·Behavioural Brain Research·Seth A Balogh, Jeanne M Wehner
Jun 24, 1998·Brain Research. Molecular Brain Research·J K PinkstaffC M Gall
Oct 16, 1999·Brain Research. Molecular Brain Research·M NapolitanoP Calabresi
Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·E HeadC W Cotman
Jan 1, 1997·Bio Systems·J DelacourD Mercier
Jan 1, 2003·Brain Research Bulletin·T L ButlerK R Pennypacker
Oct 31, 2000·Nutrition·T A Houpt
Nov 21, 2000·Current Opinion in Neurobiology·K C MartinE R Kandel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.