PMID: 2501212May 1, 1989Paper

Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region

Genomics
B ArveilerJ L Mandel

Abstract

We are using pulsed-field gel electrophoresis (PFGE) to establish a physical map of the human Xq28 region. We have identified a new probe 35.239 (DXYS64), localized in Xq28 by somatic hybrid mapping and belonging to a region of greater than 99% homology between the X and the Y chromosomes. PFGE data show that probes 35.239 and the polymorphic locus DXS115 (probe 767) map within a common 300-kb BssHII fragment. Both probes, in addition, hybridize to 575-kb BssHII and 590-kb ClaI fragments that contain the gene coding for coagulation factor VIII (F8C). The order F8C-DXS115-DXYS64 could be determined. Our results also provide evidence for linkage between the red/green color vision locus (RCP,GCP) and probes MD13 and T1.7 (GdX, DXS254) within a 750-kb ClaI fragment. Although the latter two probes are located within 50 kb of the 3' end of the G6PD gene, a G6PD cDNA probe did not hybridize to this fragment. G6PD, on the other hand, could be linked to F8C on a 290-kb BssHII fragment. All these data allow us to propose the order (RCP,GCP)-MD13-GdX-G6PD-F8C-DXS115-DXYS 64. We also linked probes St14 (DXS52), MN12 (DXS33), and DX13 (DXS15) to a member of a small family of X-linked dispersed sequences (DNF22S3) within a 575-kb BssHII frag...Continue Reading

References

Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D TonioloM Alcalay
Jun 17, 1988·Science·D VollrathR W Davis
Mar 25, 1987·Nucleic Acids Research·M PattersonK E Davies
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Citations

May 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B R Jordan
Feb 6, 1998·Human Mutation·L VitsP J Willems
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A L JørgensenA G Motulsky
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M J HigginsM Lalande
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A PoustkaH Lehrach
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P H YenL J Shapiro
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G H SackH W Moser
Feb 1, 1991·American Journal of Medical Genetics·L M Spano, J M Opitz
Feb 1, 1991·American Journal of Medical Genetics·W T BrownE C Jenkins
Jan 1, 1992·Survey of Ophthalmology·M A Musarella
Oct 15, 1991·Hospital Practice·C T Caskey

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