Toward a prefrontal microcircuit model for cognitive deficits in schizophrenia

Pharmacopsychiatry
X-J Wang

Abstract

I present here a biophysically-based model of cortical microcircuits capable of both internal representation (memory storage) and dynamical processing (decision and action selection). The model is illustrated through computer simulations that account for neurophysiological and behavioral data from studies using nonhuman primates. This computational theory proposes that an interplay between slow reverberating excitation and competitive synaptic inhibition enables a cortical area, such as the prefrontal cortex, to subserve cognitive functions. It is argued that quantitatively accurate microcircuit models can potentially provide a framework for a systematic approach to pharmacological treatment of schizophrenia and other mental disorders.

Citations

Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A Lewis, Guillermo González-Burgos
Mar 18, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Ahmed A Moustafa, Mark A Gluck
Sep 21, 2010·Neuroscience and Biobehavioral Reviews·Edmund T Rolls, Gustavo Deco
Dec 3, 2014·Neuron·Xiao-Jing Wang, John H Krystal
Oct 30, 2008·Neuron·Xiao-Jing Wang
Jul 24, 2008·Neuropsychologia·Frédéric Lavigne, Nelly Darmon
May 15, 2016·Biochimica Et Biophysica Acta·Zhen QiEberhard O Voit
Sep 9, 2006·Nature Medicine·David A Lewis, Guillermo Gonzalez-Burgos
Aug 21, 2008·Nature Reviews. Neuroscience·Edmund T RollsGeorg Winterer
Jun 13, 2020·Frontiers in Psychology·Nicola Riccardo PolizzottoRaymond Y Cho

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