Toward a standardized structural-functional group connectome in MNI space

NeuroImage
Andreas Horn, Felix Blankenburg

Abstract

The analysis of the structural architecture of the human brain in terms of connectivity between its subregions has provided profound insights into its underlying functional organization and has coined the concept of the "connectome", a structural description of the elements forming the human brain and the connections among them. Here, as a proof of concept, we introduce a novel group connectome in standard space based on a large sample of 169 subjects from the Enhanced Nathan Kline Institute-Rockland Sample (eNKI-RS). Whole brain structural connectomes of each subject were estimated with a global tracking approach, and the resulting fiber tracts were warped into standard stereotactic (MNI) space using DARTEL. Employing this group connectome, the results of published tracking studies (i.e., the JHU white matter and Oxford thalamic connectivity atlas) could be largely reproduced directly within MNI space. In a second analysis, a study that examined structural connectivity between regions of a functional network, namely the default mode network, was reproduced. Voxel-wise structural centrality was then calculated and compared to others' findings. Furthermore, including additional resting-state fMRI data from the same subjects, str...Continue Reading

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Pajevic, C Pierpaoli
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K E StephanR Kötter
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Mar 16, 2005·International Journal of Health Services : Planning, Administration, Evaluation·UNKNOWN US Census Bureau
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher J HoneyOlaf Sporns
Jul 6, 2007·PloS One·Patric HagmannJean-Philippe Thiran
Sep 1, 2007·NeuroImage·John Ashburner
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B W KreherV G Kiselev
Oct 11, 2008·PLoS Computational Biology·Anandamohan GhoshV K Jirsa
Jan 20, 2009·IEEE Transactions on Medical Imaging·Andrew Zalesky, Alex Fornito
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·C J HoneyP Hagmann
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Jun 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gustavo DecoRolf Kötter
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Silvina G HorovitzJeff H Duyn
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Nov 6, 2009·Journal of Neurophysiology·Koene R A Van DijkRandy L Buckner
Feb 2, 2010·NeuroImage·Christopher J HoneyOlaf Sporns
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
Apr 28, 2010·Cerebral Cortex·Peter FranssonHugo Lagercrantz
Sep 22, 2010·NeuroImage·Marco ReisertValerij Kiselev
Nov 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martijn P van den HeuvelHilleke E Hulshoff Pol
Dec 21, 2010·Nature Reviews. Neuroscience·Gustavo DecoAnthony R McIntosh
Apr 5, 2011·NeuroImage·Mikail Rubinov, Olaf Sporns
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew J BrookesPeter G Morris
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gustavo Deco, Viktor K Jirsa
Jun 19, 2012·Neurosurgery·Arthur W TogaJohn Darrell Van Horn

❮ Previous
Next ❯

Citations

Jun 7, 2017·Annals of Neurology·Andreas HornMichael D Fox
Mar 8, 2019·Current Opinion in Neurology·Andreas Horn
Aug 5, 2019·Brain : a Journal of Neurology·Bassam Al-FatlyAndrea A Kühn
Aug 15, 2019·Brain : a Journal of Neurology·Andreas HornAndrea A Kühn
Jul 24, 2020·Brain Imaging and Behavior·Hui HeDezhong Yao
Aug 9, 2020·Brain Imaging and Behavior·Davide MomiEmiliano Santarnecchi
Jun 18, 2016·Journal of the International Neuropsychological Society : JINS·Deanna M BarchStephen M Rao
Sep 17, 2020·Scientific Data·Clemens NeudorferAndres M Lozano
Dec 11, 2020·Brain : a Journal of Neurology·Yasmine M KehnemouyiHelen M Bronte-Stewart
Dec 1, 2020·Annals of Neurology·Gavin J B EliasAndres M Lozano
Jun 9, 2020·NeuroImage·Svenja TreuAndreas Horn
Dec 10, 2020·Cell Reports·Gustavo Deco, Morten L Kringelbach
Jan 6, 2021·Nature Human Behaviour·Gustavo DecoMorten L Kringelbach
Dec 12, 2020·Frontiers in Human Neuroscience·Benjamin DavidsonClement Hamani
Dec 18, 2020·Frontiers in Psychiatry·Lescia K TremblayRussell J Schachar
Mar 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christopher G Schwarz
Apr 25, 2021·Nature Communications·Julian Q KosciessaDouglas D Garrett
Aug 27, 2021·Current Biology : CB·Gustavo DecoMorten L Kringelbach
Oct 1, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Matthias BussasMark Mühlau
Nov 9, 2021·Frontiers in Neuroscience·Xenia KobelevaGustavo Deco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.