Toward an acoustic noninvasive diagnosis of urinary bladder outlet obstruction

IEEE Transactions on Bio-medical Engineering
Tim IdzengaRon van Mastrigt

Abstract

On average, in aging males, the prostate enlarges (benign prostatic enlargement or BPE) and may cause bladder outlet obstruction (BOO). The internationally standardized method for diagnosing BOO is based on measurements of urinary flow rate and bladder pressure, using a catheter inserted into the bladder via the urethra. This method is invasive, time-consuming, and uncomfortable for the patient. We are developing a novel diagnostic method based on perineal recording of sound during urinary flow. Although it is known that (some aspects of) the recorded sound are (among others) related to the degree of obstruction, an exact and unique relation allowing derivation of the degree of obstruction from the sound recording is not known. In a biophysical model of the urethra, we found that the weighted average frequency, the standard deviation, and the skewness of the power spectrum are monotonically related to the degree of obstruction. The standard deviation was the most significant predictor of BOO (89% correct). Based on this model study, we are confident that a simple noninvasive acoustic method for diagnosing BOO caused by BPE can be developed. This would lower the threshold for urodynamic testing of patients with lower urinary tra...Continue Reading

References

Nov 27, 1975·The New England Journal of Medicine·G W DuncanR S Lees
Apr 1, 1977·The Journal of the Acoustical Society of America·J J Fredberg
Jan 1, 1976·Journal of Biomechanics·R J Tobin, I D Chang
Jul 1, 1991·Medical & Biological Engineering & Computing·H Teriö
Jan 1, 1988·The Journal of the Acoustical Society of America·S A Abdallah, N H Hwang
Jan 1, 1987·Journal of Biomechanics·S A Jones, A Fronek
Apr 1, 1974·Bulletin of Mathematical Biology·J J Fredberg
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·R S Lees, C F Dewey
Jan 1, 1983·Journal of Biomechanics·P C LuN H Hwang
Aug 20, 1981·The New England Journal of Medicine·J P KistlerG Roberson
Feb 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K C Chu, B K Rutt
Oct 26, 1999·Neurourology and Urodynamics·D PorruE Usai
Feb 8, 2002·The Journal of Urology·C J GriffithsP D Ramsden
May 3, 2006·Neurourology and Urodynamics·Matthias OelkeHessel Wijkstra

❮ Previous
Next ❯

Citations

May 5, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Tim IdzengaRon van Mastrigt
Dec 7, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Elizabeth MurrayKirrie J Ballard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.