Toward an Alternative Therapeutic Approach for Skin Infections: Antagonistic Activity of Lactobacilli Against Antibiotic-Resistant Staphylococcus aureus and Pseudomonas aeruginosa

Probiotics and Antimicrobial Proteins
Mohamed M HafezNoha M Zaki

Abstract

The wide spread of antimicrobial resistance has urged the need of alternative therapeutic approach. In this context, probiotic lactobacilli have been reported for the prevention and treatment of many gastrointestinal and urogenital infections. However, very little is known about their antagonistic activity against skin pathogens. Accordingly, the present study aimed to investigate the potential of lactobacilli to interfere with pathogenesis features of two antibiotic-resistant skin pathogens, namely methicillin-resistant Staphylococcus aureus and multiple-resistant Pseudomonas aeruginosa. A total of 49 lactobacilli were recovered, identified and tested for their antagonistic activities against the aforementioned pathogens. Of these, eight isolates were capable of blocking the adherence of pathogens to mammalian cells independent of the skin pathogen tested or model adopted. Moreover, three Lactobacillus isolates (LRA4, LC2 and LR5) effectively prevented the pathogen internalization into epithelial cells in addition to potentiating phagocyte-mediated pathogen killing. Interestingly, the lactobacilli LC2, LF9 and LRA4 markedly inhibited the growth of P. aeruginosa and S. aureus isolates in coculture experiments. Besides, the lact...Continue Reading

References

Sep 1, 1991·Journal of Epidemiology and Community Health·D M Fleming
Jun 10, 1995·BMJ : British Medical Journal·E BrownG Hewett
Jan 1, 1996·Annual Review of Immunology·B D Jones, S Falkow
Aug 1, 1997·The American Journal of Clinical Nutrition·E J SchiffrinA Donnet-Hughes
Feb 7, 2001·The American Journal of Clinical Nutrition·E TuomolaS Salminen
Feb 15, 2001·FEMS Immunology and Medical Microbiology·G ReidB Henning
Jul 11, 2002·Annals of Medicine·Harry S CourtneyJames B Dale
Dec 24, 2002·Infection and Immunity·Barbara AlbigerAnn-Beth Jonsson
Nov 14, 2003·Journal of Medical Microbiology·María Silvina Juárez TomásMaría E Nader-Macías
Dec 10, 2003·Journal of Medical Microbiology·Mehran J Marouni, Shlomo Sela
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Nov 19, 2005·Microbes and Infection·Alessandra M SalibaMaria-Cristina Plotkowski
May 9, 2006·Journal of Dermatological Science·Keiji IwatsukiTakashi Oono
Feb 16, 2008·The British Journal of Dermatology·A L CogenR L Gallo
Oct 24, 2008·Journal of Pediatric Gastroenterology and Nutrition·Jon A Vanderhoof
Jan 20, 2009·Current Drug Metabolism·Maria Carmen ColladoYolanda Sanz
Dec 3, 2009·Current Opinion in Gastroenterology·Fang Yan, David Brent Polk
Jan 29, 2010·Journal of Dairy Science·K D Zinger-YosovichN Gilboa-Garber
May 15, 2010·Journal of Medical Microbiology·Abofu AlemkaBilly Bourke
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jacques RavelLarry J Forney
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jingru LiJohn K McCormick
Feb 22, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Krzysztof J ReszkaBradley E Britigan

❮ Previous
Next ❯

Citations

May 20, 2015·Annals of Clinical Microbiology and Antimicrobials·Mikayel GinovyanArmen Trchounian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.