Toward an integrative science of the developing human mind and brain: Focus on the developing cortex

Developmental Cognitive Neuroscience
Terry L JerniganAnders M Dale

Abstract

Based on the Huttenlocher lecture, this article describes the need for a more integrative scientific paradigm for addressing important questions raised by key observations made over 2 decades ago. Among these are the early descriptions by Huttenlocher of variability in synaptic density in cortex of postmortem brains of children of different ages and the almost simultaneous reports of cortical volume reductions on MR imaging in children and adolescents. In spite of much progress in developmental neurobiology, developmental cognitive neuroscience, and behavioral and imaging genetics, we still do not know how these early observations relate to each other. It is argued that large scale, collaborative research programs are needed to establish the associations between behavioral differences among children and imaging biomarkers, and to link the latter to cellular changes in the developing brain. Examples of progress and challenges remaining are illustrated with data from the Pediatric Imaging, Neurocognition, and Genetics Project (PING).

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Citations

Oct 30, 2016·Journal of Cognitive Neuroscience·Oliver BraddickTerry L Jernigan
Dec 3, 2016·Wiley Interdisciplinary Reviews. Cognitive Science·Timothy T Brown
Jan 17, 2020·Medical Teacher·Amanda B Cooper, Elizabeth J Tisdell
Mar 18, 2020·Journal of Neurotrauma·Ashley L WareKeith Owen Yeates
Sep 10, 2020·Wiley Interdisciplinary Reviews. Cognitive Science·Kathryn NaveAndy Clark
Jun 28, 2016·Journal of Child Neurology·Erin D BiglerKeith Owen Yeates
Sep 30, 2017·Frontiers in Cellular Neuroscience·Taylor Chomiak, Bin Hu
Apr 19, 2017·Brain Structure & Function·Natalie J FordePieter J Hoekstra
Jun 26, 2021·Developmental Cognitive Neuroscience·Marybel Robledo GonzalezKathrine Skak Madsen
Sep 10, 2021·Psychiatry Investigation·Yoonmi WooByung-Joo Ham

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Methods Mentioned

BETA
genotyping
GAM

Software Mentioned

package “
PING
FreeSurfer
ENIGMA
mgcv ”
PING Portal
R
package “ mgcv ”

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