Toward Building Hybrid Biological/in silico Neural Networks for Motor Neuroprosthetic Control

Frontiers in Neurorobotics
Mehmet KocaturkResit Canbeyli

Abstract

In this article, we introduce the Bioinspired Neuroprosthetic Design Environment (BNDE) as a practical platform for the development of novel brain-machine interface (BMI) controllers, which are based on spiking model neurons. We built the BNDE around a hard real-time system so that it is capable of creating simulated synapses from extracellularly recorded neurons to model neurons. In order to evaluate the practicality of the BNDE for neuroprosthetic control experiments, a novel, adaptive BMI controller was developed and tested using real-time closed-loop simulations. The present controller consists of two in silico medium spiny neurons, which receive simulated synaptic inputs from recorded motor cortical neurons. In the closed-loop simulations, the recordings from the cortical neurons were imitated using an external, hardware-based neural signal synthesizer. By implementing a reward-modulated spike timing-dependent plasticity rule, the controller achieved perfect target reach accuracy for a two-target reaching task in one-dimensional space. The BNDE combines the flexibility of software-based spiking neural network (SNN) simulations with powerful online data visualization tools and is a low-cost, PC-based, and all-in-one solutio...Continue Reading

References

Dec 1, 1996·Journal of Neurophysiology·M S FeeD Kleinfeld
Jul 11, 1998·Journal of Neurophysiology·W Schultz
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·N G HatsopoulosJ P Donoghue
Apr 30, 1999·Network : Computation in Neural Systems·M S Lewicki
Dec 29, 2000·Nature Neuroscience·L F Abbott, S B Nelson
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·W Schultz
Sep 7, 2001·Nature·J N ReynoldsJ R Wickens
Jun 8, 2002·Science·Dawn M TaylorAndrew B Schwartz
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·John N J Reynolds, Jeffery R Wickens
Nov 19, 2003·PLoS Biology·Jose M CarmenaMiguel A L Nicolelis
Dec 10, 2003·Current Opinion in Neurobiology·Jeffery R WickensBrian I Hyland
Jun 11, 2004·IEEE Transactions on Bio-medical Engineering·Justin C SanchezJose C Principe
Oct 16, 2004·IEEE Transactions on Neural Networks·Eugene M Izhikevich
Mar 12, 2005·Science·Philippe N ToblerWolfram Schultz
Jun 7, 2005·Trends in Neurosciences·Sten GrillnerMartin A Wikström
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim P Vogels, L F Abbott
May 18, 2006·Journal of Neural Engineering·Remy WahnounStephen I Helms Tillery
Jul 14, 2006·Nature·Leigh R HochbergJohn P Donoghue
May 15, 2007·Progress in Brain Research·J M TepperJ P Bolam
Feb 5, 2008·IEEE Transactions on Neural Networks·E M Izhikevich
Mar 7, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Verena Pawlak, Jason N D Kerr
May 30, 2008·Nature·Meel VellisteAndrew B Schwartz
Oct 2, 2008·Methods in Molecular Biology·Alan D DorvalJohn A White
Nov 29, 2008·Neuron·Anatol C Kreitzer, Robert C Malenka
Jan 20, 2009·Journal of Computational Neuroscience·Robert D Stewart, Wyeth Bair
Feb 20, 2009·IEEE Transactions on Bio-medical Engineering·Jack DiGiovannaJustin C Sanchez
Dec 10, 2009·PLoS Computational Biology·Eleni VasilakiWulfram Gerstner
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David PutrinoSoumya Ghosh
Sep 23, 2010·Frontiers in Neuroscience·John D RolstonSteve M Potter
Oct 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas FrémauxWulfram Gerstner
Nov 26, 2010·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Risa J LinRobert J Butera
Mar 9, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Subramaniam Venkatraman, Jose M Carmena
Mar 23, 2011·PloS One·Babak Mahmoudi, Justin C Sanchez
Apr 19, 2011·Nature Neuroscience·Karunesh GangulyJose M Carmena
Jul 13, 2011·Frontiers in Neuroscience·Giacomo IndiveriKwabena Boahen
Aug 17, 2011·Frontiers in Neuroinformatics·Tilman J KisperskyJohn A White
Sep 24, 2011·Frontiers in Neuroinformatics·Jan GreweJan Benda
Oct 19, 2011·Frontiers in Synaptic Neuroscience·Henry MarkramPer Jesper Sjöström
Mar 23, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Theodore W BergerJohn J Granacki
Oct 25, 2012·PloS One·George L ChadderdonWilliam W Lytton

❮ Previous
Next ❯

Citations

Feb 24, 2016·Frontiers in Neuroscience·Salvador Dura-BernalWilliam W Lytton
Oct 28, 2016·PloS One·Hoang-Dung NguyenYong-Il Shin
Jun 3, 2017·Journal of Neural Engineering·Frédéric D BroccardGert Cauwenberghs
Feb 5, 2016·The Journal of Physiology·Peter StrattonMichael Milford
Dec 5, 2017·IBM Journal of Research and Development·S Dura-BernalW W Lytton
Jul 24, 2018·Frontiers in Neurorobotics·Zhenshan BingAlois C Knoll
Dec 6, 2018·Biomedical Engineering Online·Hoang-Dung NguyenKeum-Shik Hong

❮ Previous
Next ❯

Methods Mentioned

BETA
chips

Software Mentioned

SNN
RELACS
NeuroRighter
Linux
Sim0
gtkdatabox
RTAI
RTXI
Ubuntu Linux
Bioinspired Neuroprosthetic Design Environment ( BNDE ) BNDE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jessica JimenezJose M Carmena
Neural Networks : the Official Journal of the International Neural Network Society
Shuangming YangHuiyan Li
IEEE Transactions on Neural Networks
Eduardo RosMichael Arnold
© 2021 Meta ULC. All rights reserved