Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Frontiers in Bioengineering and Biotechnology
Marta Mazzola, Elisa Di Pasquale

Abstract

Cardiovascular diseases represent the major cause of morbidity and mortality worldwide. Multiple studies have been conducted so far in order to develop treatments able to prevent the progression of these pathologies. Despite progress made in the last decade, current therapies are still hampered by poor translation into actual clinical applications. The major drawback of such strategies is represented by the limited regenerative capacity of the cardiac tissue. Indeed, after an ischaemic insult, the formation of fibrotic scar takes place, interfering with mechanical and electrical functions of the heart. Hence, the ability of the heart to recover after ischaemic injury depends on several molecular and cellular pathways, and the imbalance between them results into adverse remodeling, culminating in heart failure. In this complex scenario, a new chapter of regenerative medicine has been opened over the past 20 years with the discovery of induced pluripotent stem cells (iPSCs). These cells share the same characteristic of embryonic stem cells (ESCs), but are generated from patient-specific somatic cells, overcoming the ethical limitations related to ESC use and providing an autologous source of human cells. Similarly to ESCs, iPSCs ...Continue Reading

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Citations

Jul 29, 2020·Frontiers in Physiology·Silvia CrastoElisa Di Pasquale
Oct 3, 2020·Inflammation and Regeneration·Kozue MurataHidetoshi Masumoto
Oct 22, 2020·International Journal of Molecular Sciences·Antonia MancusoDonatella Paolino
May 8, 2021·World Journal of Stem Cells·Mathieu Rheault-HenryRony Atoui
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Tarun AgarwalCarmelo De Maria
Jun 29, 2021·Frontiers in Bioengineering and Biotechnology·Asher Kahn-KrellJianyi Zhang
Aug 10, 2021·Bioelectrochemistry·Carly BoyeAnna Bulysheva
Dec 16, 2020·ACS Biomaterials Science & Engineering·Ali MousaviHossein Baharvand
Aug 20, 2021·Current Cardiology Reports·Devika KirMrudula R Munagala

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Methods Mentioned

BETA
coronary artery ligation
bioprinting
bio-hybrid
biopsy

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