Three-dimensional definition of two prominent deep brain stimulation targets based on a multimodal high-definition MNI template

BioRxiv : the Preprint Server for Biology
Siobhan Ewert, Philip Plettig

Abstract

Three-dimensional atlases of subcortical brain structures are valuable tools to reference anatomy in neuroscience and neurology. In the special case of deep brain stimulation (DBS), the two most prominent targets are the subthalamic nucleus (STN) and the internal part of the pallidum (GPi). With the help of atlases that define their position and shape within a well-defined stereotactic space, their spatial relationship to implanted deep brain stimulation (DBS) electrodes may be analyzed on a single-subject level and in group studies. One standard approach to define such atlases is to manually segment structures on MR data of large cohorts and coregister them to a standard anatomy template. Other approaches include using histological stacks that are again co-registered to the template. However, most of the atlases derived in this fashion show a substantial descripancy to the anatomy that is defined by the template itself. Here, an algorithm that automatically segments the template itself by simultaneously using its T1, T2, proton density and T2 relaxometry modalities is introduced. Based on a low number of manually placed point fiducials within each structure, this three-level algorithm was able to robustly segment subcortical a...Continue Reading

Related Concepts

Study
Entire Red Nucleus
Biologic Segmentation
Positioning Attribute
Histology Procedure
Globus Pallidus
Magnetic Resonance Imaging
Three-dimensional
Anatomic Structures
Spatial Distribution

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