Toward Development of iMesenchymal Stem Cells for Immunomodulatory Therapy

Frontiers in Immunology
Samantha F H de WitteM J Hoogduijn

Abstract

Mesenchymal stem cells (MSC) are under development as an immunomodulatory therapy. The anticipated immunomodulatory effects of MSC are broad, from direct inhibition of lymphocyte proliferation, induction of regulatory T and B cells, to resetting the immune system via a hit-and-run principle. There are endless flavors of MSC. Differences between MSC are originating from donors variation, differences in tissue of origin, the effects of culture conditions, and expansion time. Even standard culture conditions change the properties of MSC dramatically and generate MSC that only remotely resemble their in vivo counterparts. Adjustments in culture protocols can further emphasize properties of interest in MSC, thereby generating cells fitted for specific purposes. Culture improved immunomodulatory MSC can be designed to target particular immune disorders. In this review, we describe the observed and the desired immunomodulatory effects of MSC and propose approaches how MSC with optimal immunomodulatory properties can be developed.

References

Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
Mar 31, 2007·Stem Cells·Federica BenvenutoAntonio Uccelli
Oct 3, 2007·Blood·Patricia S ChoChristene A Huang
Feb 1, 2008·American Journal of Physiology. Cell Physiology·Paul R CrisostomoDaniel R Meldrum
May 22, 2008·European Journal of Immunology·David PolchertAmelia Bartholomew
Jan 16, 2009·International Journal of Laboratory Hematology·A NasefA Chapel
Jul 16, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Moutih RafeiJacques Galipeau
Sep 24, 2009·Experimental Hematology·Jaehyup Kim, Peiman Hematti
Feb 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guangwen RenYufang Shi
Jul 14, 2010·International Immunopharmacology·Martin J HoogduijnMarc-H Dahlke
Mar 15, 2011·Cell Transplantation·Meindert J CropMartin J Hoogduijn
Sep 29, 2011·American Journal of Reproductive Immunology : AJRI·Ehsan SoleymaninejadianEsmaeil Samadian
Apr 11, 2012·Trends in Immunology·Paul A BeavisMark J Smyth
Oct 6, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Gijs H Goossens, Ellen E Blaak
Dec 4, 2012·Clinical and Experimental Immunology·F S RegateiroH Waldmann

❮ Previous
Next ❯

Citations

Apr 6, 2017·Frontiers in Veterinary Science·Javier G CasadoFrancisco Miguel Sánchez-Margallo
Sep 19, 2020·International Journal of Molecular Sciences·Santiago RouraFrancesc E Borràs
Jul 14, 2020·Frontiers in Veterinary Science·Valeria CaffiClaudio Henríquez
Nov 30, 2016·Frontiers in Immunology·Monica ReisAnne Richter
Jun 9, 2018·Frontiers in Immunology·Soraia Carvalho AbreuPatricia Rieken Macêdo Rocco
Sep 14, 2018·Stem Cells International·Ross E B FitzsimmonsCraig A Simmons
Jul 19, 2019·Frontiers in Pharmacology·Rebeca BlázquezJavier G Casado
Jul 14, 2020·Frontiers in Endocrinology·Masahiro MaruyamaStuart B Goodman
Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Stuart B Goodman, Tzuhua Lin
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Ghada BeldiSina Naserian
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ana Mora-BozaJulio San Román
Jan 21, 2021·International Journal of Molecular Sciences·Vitale MiceliPier Giulio Conaldi
Jul 13, 2021·Frontiers in Immunology·Ayman F RefaieMohamed A Ghoneim
Oct 8, 2021·Frontiers in Bioengineering and Biotechnology·Carlotta Perucca OrfeiLaura de Girolamo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.