Abstract
Several distinct chromosomal segments were recently identified by cosegregation analysis of polymorphic markers with antibody responsiveness in an F2 cross between high (H) and low (L) antibody responder lines of Biozzi mice. The effect associated with the relevant markers has now been investigated in backcross populations (toward the L line) bred from H and L mice made coisogenic at the H-2 locus. The antibody titers, measured on days 5 and 14 of the primary response to sheep red blood cells, were considered to be two distinct quantitative phenotypes. The results of single or multilocus analyses demonstrated the significant involvement, at one or the two titration times, of Im gene(s) on four distinct chromosomes: 4, 8, 12, and 18. The regions on chromosomes 6 and 10 have a lesser but still suggestive effect. The contribution of each locus ranged from 3% to 13%, and together these loci accounted for about 40% of the phenotypic variance at each titration time. The data are compatible with an additive effect of the relevant loci and suggestive of some interaction effects. In a second backcross toward L line, the H line alleles of the putative Im genes on chromosomes 6, 8, and 12 were isolated from each other and their effects we...Continue Reading
References
Jan 1, 1976·European Journal of Immunology·N FeingoldG Biozzi
Jun 1, 1992·Genetics·W DietrichE S Lander
Jan 1, 1990·Immunogenetics·L VidardM Seman
Oct 1, 1972·The Journal of Experimental Medicine·R LiebermanB Benacerraf
May 1, 1972·The Journal of Experimental Medicine·G BiozziC Decreusefond
Jan 1, 1984·Advances in Immunology·G BiozziY Bouthillier
Jan 1, 1981·Infection and Immunity·E S Metcalf, A D O'Brien
Oct 1, 1995·Nature Genetics·G T De SanctisJ M Drazen
Nov 1, 1995·Nature Genetics·E Lander, L Kruglyak
Mar 1, 1995·Immunology Today·A N Theofilopoulos
Nov 1, 1994·Genetics·R C Jansen
Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Jun 1, 1994·Immunity·L MorelE K Wakeland
Jun 1, 1994·Nature Genetics·W F DietrichR D Dredge
Apr 1, 1994·Genetics·Z B Zeng
Jul 1, 1994·Science·E Marshall
Jan 1, 1993·Annual Review of Genetics·S D Tanksley
Mar 25, 1994·Science·L AnderssonI Hansson
Jun 17, 1994·Science·J C CrabbeK J Buck
Sep 1, 1993·Genetics·R C Jansen
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J D SudweeksC Teuscher
Apr 18, 1996·Nature·K TakedaS Akira
Apr 18, 1996·Nature·K ShimodaJ N Ihle
Aug 1, 1996·Nature Genetics·S RubattuK Lindpaintner
Apr 1, 1996·Current Opinion in Immunology·J Stavnezer
Jan 1, 1996·Critical Reviews in Immunology·A Puel, D Mouton
Citations
Sep 29, 2005·Immunogenetics·Camille BonneaudGabriele Sorci
Oct 1, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carla M de SouzaMarcelo De Franco
Jun 5, 2004·Ageing Research Reviews·Gino DoriaDaniela Frasca
Aug 18, 2005·Journal of Neuroimmunology·Sandra AmorDavid Baker
Jun 12, 2013·Veterinary Immunology and Immunopathology·Armando HeriazonBonnie A Mallard
May 12, 2001·Mechanisms of Ageing and Development·G Doria, D Frasca
Dec 30, 1999·Veterinary Immunology and Immunopathology·H W RaadsmaA M Crawford
Feb 26, 2000·Vaccine·G Doria, D Frasca
Aug 26, 1998·Scandinavian Journal of Immunology·G M LimaD Mouton
Feb 26, 1998·Immunological Reviews·G Doria, D Frasca
Jan 23, 1999·Immunological Reviews·R J StetG F Wiegertjes
Jun 1, 2005·BMC Genetics·Oxana Norkina, Robert C De Lisle
Mar 24, 2007·PLoS Medicine·Chantal BaronClaude Perreault
Aug 11, 2011·PloS One·Laurence FloriClaire Rogel-Gaillard
Sep 21, 2011·Veterinary Immunology and Immunopathology·Armando HeriazonBonnie A Mallard
Dec 23, 2003·Animal Genetics·M SiwekJ J van der Poel
Jan 12, 2008·International Journal of Immunogenetics·K WimmersS Ponsuksili
Jul 29, 2015·Poultry Science·Tuoyu GengEdward J Smith
May 11, 2016·Expert Review of Vaccines·Gabriela Navarro-TovarSergio Rosales-Mendoza
Nov 4, 2000·International Immunology·L M AraujoA Herbelin
May 14, 2003·Immunogenetics·Huaijun Zhou, Susan J Lamont
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·A SaranG Biozzi