PMID: 8962125Dec 10, 1996Paper

Toward genetic dissection of high and low antibody responsiveness in Biozzi mice

Proceedings of the National Academy of Sciences of the United States of America
A PuelD Mouton

Abstract

Several distinct chromosomal segments were recently identified by cosegregation analysis of polymorphic markers with antibody responsiveness in an F2 cross between high (H) and low (L) antibody responder lines of Biozzi mice. The effect associated with the relevant markers has now been investigated in backcross populations (toward the L line) bred from H and L mice made coisogenic at the H-2 locus. The antibody titers, measured on days 5 and 14 of the primary response to sheep red blood cells, were considered to be two distinct quantitative phenotypes. The results of single or multilocus analyses demonstrated the significant involvement, at one or the two titration times, of Im gene(s) on four distinct chromosomes: 4, 8, 12, and 18. The regions on chromosomes 6 and 10 have a lesser but still suggestive effect. The contribution of each locus ranged from 3% to 13%, and together these loci accounted for about 40% of the phenotypic variance at each titration time. The data are compatible with an additive effect of the relevant loci and suggestive of some interaction effects. In a second backcross toward L line, the H line alleles of the putative Im genes on chromosomes 6, 8, and 12 were isolated from each other and their effects we...Continue Reading

References

Mar 1, 1995·Immunology Today·A N Theofilopoulos
Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Jun 1, 1994·Nature Genetics·W F DietrichR D Dredge
Apr 1, 1994·Genetics·Z B Zeng
Jul 1, 1994·Science·E Marshall
Jan 1, 1993·Annual Review of Genetics·S D Tanksley
Jun 17, 1994·Science·J C CrabbeK J Buck
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
Apr 18, 1996·Nature·K TakedaS Akira
Apr 1, 1996·Current Opinion in Immunology·J Stavnezer
Jan 1, 1996·Critical Reviews in Immunology·A Puel, D Mouton

❮ Previous
Next ❯

Citations

Oct 1, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carla M de SouzaMarcelo De Franco
Jun 5, 2004·Ageing Research Reviews·Gino DoriaDaniela Frasca
Aug 18, 2005·Journal of Neuroimmunology·Sandra AmorDavid Baker
Jun 12, 2013·Veterinary Immunology and Immunopathology·Armando HeriazonBonnie A Mallard
May 12, 2001·Mechanisms of Ageing and Development·G Doria, D Frasca
Dec 30, 1999·Veterinary Immunology and Immunopathology·H W RaadsmaA M Crawford
Feb 26, 2000·Vaccine·G Doria, D Frasca
Feb 26, 1998·Immunological Reviews·G Doria, D Frasca
Jan 23, 1999·Immunological Reviews·R J StetG F Wiegertjes
Mar 24, 2007·PLoS Medicine·Chantal BaronClaude Perreault
Aug 11, 2011·PloS One·Laurence FloriClaire Rogel-Gaillard
Sep 21, 2011·Veterinary Immunology and Immunopathology·Armando HeriazonBonnie A Mallard
Dec 23, 2003·Animal Genetics·M SiwekJ J van der Poel
May 11, 2016·Expert Review of Vaccines·Gabriela Navarro-TovarSergio Rosales-Mendoza
May 14, 2003·Immunogenetics·Huaijun Zhou, Susan J Lamont

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.