Toward miniaturized analysis of chemical identity and purity of radiopharmaceuticals via microchip electrophoresis

Analytical and Bioanalytical Chemistry
Jimmy LyR Michael van Dam

Abstract

Miniaturized synthesis of positron emission tomography (PET) tracers is poised to offer numerous advantages including reduced tracer production costs and increased availability of diverse tracers. While many steps of the tracer production process have been miniaturized, there has been relatively little development of microscale systems for the quality control (QC) testing process that is required by regulatory agencies to ensure purity, identity, and biological safety of the radiotracer before use in human subjects. Every batch must be tested, and in contrast with ordinary pharmaceuticals, the whole set of tests of radiopharmaceuticals must be completed within a short-period of time to minimize losses due to radioactive decay. By replacing conventional techniques with microscale analytical ones, it may be possible to significantly reduce instrument cost, conserve lab space, shorten analysis times, and streamline this aspect of PET tracer production. We focus in this work on miniaturizing the subset of QC tests for chemical identity and purity. These tests generally require high-resolution chromatographic separation prior to detection to enable the approach to be applied to many different tracers (and their impurities), and have...Continue Reading

References

Apr 1, 1996·Molecular Biotechnology·R P Oda, J P Landers
Apr 29, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·R JankowskyB Johannsen
Jun 21, 2006·Electrophoresis·Ulrike HolzgrabeYaser Bitar
Nov 1, 2006·Analytical Chemistry·Jonathan A VickersCharles S Henry
Oct 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wolfgang A Weber
Jun 25, 2009·Analytical Chemistry·Laura C Mecker, R Scott Martin
Feb 26, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Giuliano MarianiNaoyuki Watanabe
Jul 8, 2010·Lab on a Chip·Ingrid HoekW Mike Arnold
Dec 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andrei R GrabeklisElena V Lakarova
Jun 1, 2011·Seminars in Nuclear Medicine·Shankar Vallabhajosula
Aug 1, 1999·Analytical Chemistry·N H BingsD J Harrison
Jun 30, 2011·Cancer Biotherapy & Radiopharmaceuticals·Anjani K TiwariAnil K Mishra
Jun 28, 2012·Electrophoresis·Claudia Cianciulli, Hermann Wätzig
Jan 4, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dale L Bailey, Kathy P Willowson
Sep 13, 2013·Clinical & Developmental Immunology·Andor W J M GlaudemansAlberto Signore
Dec 19, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Zhengxin Cai, Carolyn J Anderson
Feb 19, 2014·Journal of Pharmaceutical and Biomedical Analysis·Shilin CheungR Michael van Dam
Mar 22, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·V AwasthiA Anzellotti
Apr 10, 2015·Analytical and Bioanalytical Chemistry·Jayson V PagaduanAdam T Woolley
Apr 29, 2015·EJNMMI Research·Aditya BansalTimothy R DeGrado
May 8, 2015·Science Translational Medicine·Michael V D'AmbrosioDaniel A Fletcher
Nov 6, 2015·Analytical and Bioanalytical Chemistry·V SahoreA T Woolley
Nov 26, 2015·Analytical Chemistry·Damith E W PatabadigeChristopher T Culbertson
Jan 17, 2016·Analytica Chimica Acta·Kishore K R Tetala, M A Vijayalakshmi
May 5, 2017·The Analyst·Mohamed DawodRobert T Kennedy
Aug 23, 2017·Seminars in Nuclear Medicine·Isaac M JacksonStephen Thompson
Sep 3, 2017·Analytica Chimica Acta·Noel S HaR Michael van Dam

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Citations

Sep 6, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Karla-Anne KnappH Charles Manning
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Christopher FrankPeter J H Scott
Jan 29, 2020·Analytical Chemistry·Jason JonesR Michael van Dam

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