Toward molecular imaging-driven drug development in oncology

Cancer Discovery
Elisabeth G E de VriesWouter B Nagengast

Abstract

With current testing strategies, the number of novel targeted anticancer agents will exceed our drug selection capacity. Molecular imaging is a powerful additional tool that can assist us in selecting effective drugs and help patients benefit from targeted agents. Moreover, measurement of the functional effects of such targeted agents could permit dynamic tuning of treatment selection at the earliest time point at which loss of functional effects is observed.

References

May 11, 2004·Nature Biotechnology·Peter M Smith-JonesSteven M Larson
Feb 24, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Farrokh DehdashtiMichael J Welch
Mar 9, 2006·Health Affairs·Christopher P Adams, Van V Brantner
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick J PerikElisabeth G E de Vries
Sep 6, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lakshmi SampathEva M Sevick-Muraca
Apr 9, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Milton V MarshallD Michael Olive
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wouter B NagengastElisabeth G E de Vries
Apr 20, 2010·Lancet·Howard I ScherUNKNOWN Prostate Cancer Foundation/Department of Defense Prostate Cancer Clinical Trials Consortium
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thijs H Oude MunninkElisabeth G de Vries
Oct 1, 2010·Nature·J S de Bono, Alan Ashworth

❮ Previous
Next ❯

Citations

Apr 3, 2013·European Journal of Pharmacology·Frederike BenschElisabeth G E de Vries
Jul 25, 2013·Nature Reviews. Clinical Oncology·Michail Ignatiadis, Christos Sotiriou
Oct 15, 2013·International Journal of Nanomedicine·Fei-Fei TengJin-Ming Yu
Jan 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guus A M S van DongenDanielle J Vugts
Jul 1, 2011·Drug Discovery Today. Technologies·Jan MarikNicholas van Bruggen
Mar 13, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·R SrikarRaghuraman Kannan
Dec 18, 2012·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Regine Choe, Turgut Durduran
Apr 16, 2015·TheScientificWorldJournal·Mitsuyoshi YoshimotoHirofumi Fujii
Oct 12, 2018·Oncogene·H Rudolf de BoerMarcel A T M van Vugt
Sep 14, 2019·Therapeutic Advances in Gastrointestinal Endoscopy·Shakil AhmedHelmut Neumann
Oct 24, 2020·Expert Review of Gastroenterology & Hepatology·Jouke J H van der LaanWouter B Nagengast
Nov 22, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laetitia E LambertsElisabeth G E de Vries
Dec 19, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jolien J TjalmaWouter B Nagengast
Apr 13, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yelena Y JanjigianJason S Lewis
Aug 1, 2021·Drug Discovery Today·Krishna Kanta GhoshBalázs Gulyás

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Drug Discovery
Jürgen K WillmannSanjiv S Gambhir
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Anton G T Terwisscha van ScheltingaElisabeth G E de Vries
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Wouter B NagengastElisabeth G E de Vries
Journal of Health Economics
Joseph A DiMasiHenry G Grabowski
Health Economics
Christopher P Adams, Van V Brantner
© 2021 Meta ULC. All rights reserved