Toward multifunctional "clickable" diamond nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
Manakamana KhanalSabine Szunerits

Abstract

Nanodiamonds (NDs) are among the most promising new carbon based materials for biomedical applications, and the simultaneous integration of various functions onto NDs is an urgent necessity. A multifunctional nanodiamond based formulation is proposed here. Our strategy relies on orthogonal surface modification using different dopamine anchors. NDs simultaneously functionalized with triethylene glycol (EG) and azide (-N3) functions were fabricated through a stoichiometrically controlled integration of the dopamine ligands onto the surface of hydroxylated NDs. The presence of EG functionalities rendered NDs soluble in water and biological media, while the -N3 group allowed postsynthetic modification of the NDs using "click" chemistry. As a proof of principle, alkynyl terminated di(amido amine) ligands were linked to these ND particles.

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Citations

Jan 21, 2016·ACS Applied Materials & Interfaces·Zuqin XueLuis A Colon
May 3, 2016·Journal of Colloid and Interface Science·Xiao Yan CaiLi Qun Xu
Apr 15, 2016·International Journal of Environmental Research and Public Health·Sabine SzuneritsRabah Boukherroub
Apr 4, 2017·Nanotechnology·K Turcheniuk, Vadym N Mochalin
Dec 7, 2018·Journal of Carbohydrate Chemistry·Crystal L O'NeilAlexei V Demchenko
Sep 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chiara Mauriello JimenezJean-Olivier Durand
Mar 13, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yun ZengRisheng Wang
May 14, 2019·ACS Applied Materials & Interfaces·Feng-Jen HsiehHuan-Cheng Chang

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