Toward multiomics-based next-generation diagnostics for precision medicine

Personalized Medicine
Qi WangLi Ye

Abstract

Our healthcare system is experiencing a paradigm shift to precision medicine, aiming at an early prediction of individual disease risks and targeted interventions. Whole-genome sequencing is currently gaining momentum, as it has the potential to capture all classes of genetic variation, thus providing a more complete picture of the individual's genetic makeup, which could be utilized in genetic testing; however, this will also lead to difficulties in interpreting the test results, necessitating careful integration of genomic data with other layers of information, both molecular multiomics measurements of epigenome, transcriptome, proteome, metabolome and even microbiome, as well as comprehensive information on diet, lifestyle and environment. Overall, the translation of patient-specific data into actionable diagnostic tools will be a challenging task, requiring expertise from multiple disciplines, secure data sharing in large reference databases and a strong computational infrastructure.

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Citations

Dec 14, 2019·Personalized Medicine·Ebony Torrington
Feb 23, 2021·Computational and Structural Biotechnology Journal·Otília Menyhárt, Balázs Győrffy
Jul 18, 2021·Acta neurochirurgica·Sami Abu HamdehNiklas Marklund

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Methods Mentioned

BETA
chemical
immunoprecipitation
RNA-seq
NMR
exome sequencing

Software Mentioned

CNAmet
P4
Anduril
Lemon
Tree
Embassy
Amazon Web Services
Ensembl
Galaxy
iCluster package

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