Toward precision medicine in Parkinson's disease

Annals of Translational Medicine
Lu-Lu BuJian Wang

Abstract

Precision medicine refers to an innovative approach selected for disease prevention and health promotion according to the individual characteristics of each patient. The goal of precision medicine is to formulate prevention and treatment strategies based on each individual with novel physiological and pathological insights into a certain disease. A multidimensional data-driven approach is about to upgrade "precision medicine" to a higher level of greater individualization in healthcare, a shift towards the treatment of individual patients rather than treating a certain disease including Parkinson's disease (PD). As one of the most common neurodegenerative diseases, PD is a lifelong chronic disease with clinical and pathophysiologic complexity, currently it is treatable but neither preventable nor curable. At its advanced stage, PD is associated with devastating chronic complications including both motor dysfunction and non-motor symptoms which impose an immense burden on the life quality of patients. Advances in computational approaches provide opportunity to establish the patient's personalized disease data at the multidimensional levels, which finally meeting the need for the current concept of precision medicine via achievin...Continue Reading

Citations

Jun 9, 2020·Frontiers in Cell and Developmental Biology·Lisa Maria Smits, Jens Christian Schwamborn
Nov 17, 2020·Frontiers in Neuroscience·Giovanna MorelloSebastiano Cavallaro

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