PMID: 16629386Apr 25, 2006Paper

Toward silencing the burden of malaria: progress and prospects for RNAi-based approaches

BioTechniques
Anthony E Brown, Flaminia Catteruccia

Abstract

The discovery of RNA interference (RNAi) is one of the most significant of recent years, with potential for application beyond the laboratory to the clinic. As a tool for functional genomics, RNAi has permitted the characterization of genes in organisms that had previously remained recalcitrant to targeted gene manipulation. Efforts to understand its mode of action have revealed a central role in gene regulation and host defense. Finally, as a therapeutic tool, it has shown enormous promise in the control of a large array of diseases. Here we examine how RNAi is revolutionizing malaria research in an organism, the Anopheles mosquito, that until recently was essentially resistant to genetic study, and show how its application in both the mosquito vector and the Plasmodium parasite might ultimately lead to new ways of controlling and perhaps even eradicating this devastating disease.

References

Aug 1, 1985·Annals of Tropical Medicine and Parasitology·A H FairlambW Peters
Jan 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A S Wilkins
Jun 2, 1995·Science·M R van DijkC J Janse
Jan 1, 1993·Annual Review of Cell Biology·K Drickamer, M E Taylor
Feb 12, 1998·Methods : a Companion to Methods in Enzymology·A P WatersC J Janse
May 7, 1998·Insect Biochemistry and Molecular Biology·M J EdwardsM Jacobs-Lorena
Feb 24, 2001·Annals of the New York Academy of Sciences·J H Wyss
Apr 27, 2001·Trends in Parasitology·R E Sinden, P F Billingsley
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·J G BremanG T Keusch
Jan 30, 2002·Molecular and Biochemical Parasitology·Louisa McRobert, Glenn A McConkey
May 25, 2002·Nature·Junitsu ItoMarcelo Jacobs-Lorena
Aug 9, 2002·The Journal of Biological Chemistry·Luciano A MoreiraMarcelo Jacobs-Lorena
Aug 22, 2002·EMBO Reports·Stéphanie BlandinElena A Levashina
Oct 5, 2002·Science·Robert A HoltStephen L Hoffman
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Dec 18, 2002·Genetica·G SacconeL C Polito
Feb 22, 2003·Science·Flaminia CatterucciaAndrea Crisanti
Jul 31, 2003·Nucleic Acids Research·Anthony E BrownFlaminia Catteruccia
Sep 10, 2003·Biochemical and Biophysical Research Communications·Asif MohmmedPawan Malhotra
Sep 19, 2003·Protist·Michael J Blackman
Dec 31, 2003·Cell·L AravindLouis H Miller
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Mar 27, 2004·Science·Janet Hemingway, Alister Craig
Mar 27, 2004·Science·Mike A OstaFotis C Kafatos
Apr 24, 2004·Cellular Microbiology·Elisabetta UlluTirtha Chakraborty
Jul 9, 2004·Biochemical and Biophysical Research Communications·Huiliang LiHeng Wang
Jun 18, 2005·The Journal of Experimental Biology·Romanico B G ArrighiChristos Louis
Jul 6, 2005·Current Opinion in Microbiology·Dina Vlachou, Fotis C Kafatos
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stephan MeisterLiangbiao Zheng
Sep 20, 2005·The Journal of Experimental Biology·Christina ScaliAndrea Crisanti
Oct 26, 2005·Nature Biotechnology·Flaminia CatterucciaAndrea Crisanti

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Citations

Feb 21, 2009·Parasitology Research·Mario CanalesJosé de la Fuente
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew P Scott
Oct 5, 2010·Cold Spring Harbor Protocols·Anthony ClemonsMolly Duman-Scheel
Apr 7, 2010·Annual Review of Biochemistry·Stephanie MohrNorbert Perrimon
Jun 15, 2011·PLoS Neglected Tropical Diseases·Johnathan J DalzellAaron G Maule
Apr 5, 2007·Nature Protocols·Neil F LoboFrank H Collins
Sep 4, 2007·Reviews in Medical Virology·Luis Isamu Barros KanzakiEnrique R Argañaraz
Jun 4, 2008·Nature Reviews. Genetics·Michael Boutros, Julie Ahringer

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