Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production

Biotechnology Journal
Helene Lunde RobertsenSang Yup Lee

Abstract

Streptomycetes are known for their inherent ability to produce pharmaceutically relevant secondary metabolites. Discovery of medically useful, yet novel compounds has become a great challenge due to frequent rediscovery of known compounds and a consequent decline in the number of relevant clinical trials in the last decades. A paradigm shift took place when the first whole genome sequences of streptomycetes became available, from which silent or "cryptic" biosynthetic gene clusters (BGCs) were discovered. Cryptic BGCs reveal a so far untapped potential of the microorganisms for the production of novel compounds, which has spurred new efforts in understanding the complex regulation between primary and secondary metabolism. This new trend has been accompanied with development of new computational resources (genome and compound mining tools), generation of various high-quality omics data, establishment of molecular tools, and other strain engineering strategies. They all come together to enable systems metabolic engineering of streptomycetes, allowing more systematic and efficient strain development. In this review, the authors present recent progresses within systems metabolic engineering of streptomycetes for uncovering their hi...Continue Reading

References

Jan 4, 2003·Nature Biotechnology·John Hodgson
Jul 15, 2004·Advances in Applied Microbiology·Bertolt GustKeith F Chater
Dec 17, 2004·Journal of the American Chemical Society·Francisco Barona-GómezGregory L Challis
Apr 9, 2005·The Journal of Antibiotics·János Bérdy
Jun 3, 2005·Genome Research·Irina BorodinaJens Nielsen
Jan 13, 2006·Nature Chemical Biology·Sylvie LautruGregory L Challis
Jul 9, 2008·The Journal of Biological Chemistry·Irina BorodinaJens Nielsen
Jan 10, 2009·The Journal of Antibiotics·Arnold L Demain, Sergio Sanchez
Jan 8, 2010·BMC Genomics·Kay NieseltElizabeth M H Wellington
May 18, 2010·Applied Microbiology and Biotechnology·Theresa SieglAndriy Luzhetskyy
Feb 24, 2011·Microbial Biotechnology·Juan Pablo Gomez-Escribano, Mervyn J Bibb
May 26, 2011·Natural Product Reports·Gilles P van Wezel, Kenneth J McDowall
Sep 24, 2013·Nature Biotechnology·Maulik N ThakerGerard D Wright
Mar 19, 2014·International Journal of Medical Microbiology : IJMM·Tilmann Weber
May 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mohammad R Seyedsayamdost
Sep 30, 2014·Nature Chemical Biology·James R DoroghaziWilliam W Metcalf
Nov 19, 2014·Scientific Reports·Lorena T Fernández-Martínez, Mervyn J Bibb
Nov 28, 2014·Nucleic Acids Research·Guy E ZinmanZiv Bar-Joseph
Dec 18, 2014·Nature Chemical Biology·Samuel E Weinberg, Navdeep S Chandel
Feb 18, 2015·Nature Chemical Biology·Chad W Johnston, Nathan A Magarvey
Mar 26, 2015·ACS Synthetic Biology·Yaojun TongSang Yup Lee
May 8, 2015·Nucleic Acids Research·Tilmann WeberMarnix H Medema
Jun 19, 2015·Biotechnology Advances·Usama Ramadan AbdelmohsenUte Hentschel
Jul 19, 2015·Applied and Environmental Microbiology·Yvonne MastEva Schinko
Jul 21, 2015·Drug Discovery Today. Technologies·Changsheng WuYoung Hae Choi
Sep 10, 2015·ACS Chemical Biology·Sheila M Pimentel-ElardoJustin R Nodwell
Oct 9, 2015·Nature Biotechnology·Sang Yup Lee, Hyun Uk Kim
Nov 4, 2015·Nucleic Acids Research·Areski FlissiMaude Pupin
Apr 9, 2016·Current Opinion in Biotechnology·Oksana Bilyk, Andriy Luzhetskyy
Apr 14, 2016·Natural Product Reports·Mingzi M ZhangHuimin Zhao

❮ Previous
Next ❯

Citations

Aug 18, 2018·Biotechnology Journal·Omkar S MohiteSang Yup Lee
Aug 15, 2019·Microbial Cell Factories·Dipesh DhakalRamesh Prasad Pandey
May 22, 2018·Frontiers in Microbiology·Learn-Han LeeBey-Hing Goh
May 18, 2019·Scientific Reports·Kattia Núñez-MonteroLeticia Barrientos
Sep 25, 2019·Antibiotics·Sudarshan Singh Thapa, Anne Grove
Jan 29, 2020·Applied Microbiology and Biotechnology·Yong ShengQianjin Kang
Nov 21, 2020·Journal, Genetic Engineering & Biotechnology·Krishika Sambyal, Rahul Vikram Singh
Sep 22, 2018·Metabolic Engineering·Liliya HorbalAndriy Luzhetskyy
Feb 12, 2020·Synthetic and Systems Biotechnology·Bin Wang, Huimin Zhao
May 12, 2021·Chembiochem : a European Journal of Chemical Biology·Catherine AubertSebastien Roy
Dec 25, 2021·Natural Product Reports·Mandy B HulstMikko Metsä-Ketelä

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.