Toward targeting inflammasomes: insights into their regulation and activation.

Cell Research
Shelbi ChristgenThirumala-Devi Kanneganti

Abstract

Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage. A number of innate immune receptors have been reported to serve as inflammasome sensors. Activation of these sensors leads to the proteolytic activation of caspase-1, a proinflammatory caspase responsible for the cleavage of proinflammatory cytokines interleukin-1β and interleukin-18 and the effector of pyroptotic cell death, gasdermin D. Though crucial to the innate immune response to infection, dysregulation of inflammasome activation can lead to the development of inflammatory diseases, neurodegeneration, and cancer. Therefore, clinical interest in the modulation of inflammasome activation is swiftly growing. As such, it is imperative to develop a mechanistic understanding of the regulation of these complexes. In this review, we divide the regulation of inflammasome activation into three parts. We discuss the transcriptional regulation of inflammasome components and related proteins, the post-translational mechanisms of inflammasome activation, and advances in the understanding of the structural basis of inflammasome activation.

References

Feb 1, 1995·Molecular and Cellular Biology·V BrikenP Staeheli
Nov 1, 1996·Neurochemistry International·K AlheimT Bartfai
Sep 1, 1997·Nature Genetics·UNKNOWN French FMF Consortium
Jan 13, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J D MarshallG Trinchieri
Jan 26, 1999·Annals of the New York Academy of Sciences·C A Dinarello
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J PurenC A Dinarello
Nov 24, 1999·The Journal of Biological Chemistry·J MasumotoJ Sagara
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y M KimI Choi
Dec 19, 2000·Scandinavian Journal of Immunology·U KalinaO G Ottmann
Jun 14, 2002·Biochemical and Biophysical Research Communications·Zhiyong YangPhilip E Auron
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobue TakedaTakeshi Tokuhisa
Oct 7, 2004·The American Journal of Pathology·Annalisa R StonePaula M Vertino
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
Jan 28, 2006·The Journal of Biological Chemistry·Michael D LiangBarbara S Nikolajczyk
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoyoshi EndoTomomi Gotoh
Jan 5, 2007·Annual Review of Immunology·Hyun Ho ParkHao Wu
Jan 12, 2007·Genes and Immunity·S R Thompson, S E Humphries
Jun 30, 2007·Cell Death and Differentiation·V PétrilliJ Tschopp
Aug 30, 2007·The FEBS Journal·Nishant JainGhanshyam Swarup
Aug 23, 2008·Genes and Immunity·J P AndersonH M Hoffman
Jan 23, 2009·Nature·Teresa Fernandes-AlnemriEmad S Alnemri
Mar 28, 2009·The Journal of Biological Chemistry·Mary E LucasPaula M Vertino
Jul 3, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franz G BauernfeindEicke Latz
Oct 9, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jürgen HarderGabriel Núñez
Feb 13, 2010·Cellular Microbiology·Bibhuti B MishraElsa Anes
Apr 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xianbao HeRobin R Ingalls

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Aleksandar ArsenijevicMarija Milovanovic
Aug 30, 2020·Cell Research·Chenqi XuRichard A Flavell
Aug 17, 2020·International Journal of Molecular Sciences·Giulia PoliStefano Brancorsini
Jul 8, 2020·International Journal of Molecular Sciences·Jae-Min YukEun-Kyeong Jo
Aug 23, 2020·International Journal of Molecular Sciences·Chiara PanicucciClaudio Bruno
Sep 24, 2020·International Journal of Molecular Sciences·Savita DeviAndrea Dorfleutner
Aug 30, 2020·Seminars in Cell & Developmental Biology·Vik Ven EngJaclyn S Pearson
Jan 30, 2021·Neural Regeneration Research·Jing ChenHe-Zuo Lü
Dec 10, 2020·Journal of Inflammation Research·Javier Checa, Josep M Aran
Jan 13, 2021·International Journal of Molecular Sciences·Valeria Di BattistaAlessandro Lucchesi
Dec 4, 2020·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wenqi YangLiangming Li
Oct 13, 2020·Biochemical and Biophysical Research Communications·Wen ZhangXiao-Ming Yang
Feb 20, 2021·Nature Immunology·Katherine A Deets, Russell E Vance
Mar 13, 2021·Frontiers in Immunology·Sharon Db de MoraisTammy Kielian
Mar 13, 2021·Nature Immunology·Bhesh Raj Sharma, Thirumala-Devi Kanneganti
Mar 17, 2021·Molecular Immunology·William J GilmoreMaria Kaparakis-Liaskos
Mar 30, 2021·Frontiers in Pharmacology·Jonathan A HolbrookMichael F McDermott
Apr 14, 2021·Immunology Letters·Lukas HatscherDiana Dudziak
May 28, 2021·Immunology·Jean Gabriel de SouzaOlga Celia Martinez Ibañez
Jul 6, 2021·RSC Medicinal Chemistry·Silke Miller, Maria-Jesus Blanco
May 23, 2021·Immunology·Jessica CarriereChristian Stehlik
Jul 25, 2021·International Journal of Molecular Sciences·Young-Su Yi
Aug 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Eunsoo KimProsper N Boyaka
Aug 13, 2021·Aging Cell·Thassio MesquitaAhmed Ibrahim
Nov 15, 2020·Molecular Aspects of Medicine·Kevin P DownsChristian Stehlik
Sep 3, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yujin HongKwangseog Ahn
Sep 20, 2021·Journal of Molecular Biology·Lam Nhat Nguyen, Thirumala-Devi Kanneganti
Sep 12, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hannah ScheiblichMichael T Heneka

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Methods Mentioned

BETA
GTPase
immunoprecipitation
electrophoretic
ChIP
ubiquitination
X-ray
nuclear magnetic resonance
dissection

Software Mentioned

Pycard

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