PMID: 8939639Dec 1, 1996Paper

Toward the development of DNA vaccines

Current Opinion in Biotechnology
J B UlmerM A Liu

Abstract

DNA vaccination has proved to be a generally applicable technology in various preclinical animal models of infectious and noninfectious disease and several DNA vaccines have now entered phase I human clinical trials. It is too early to predict the effectiveness of DNA vaccines in humans and whether improved formulations of DNA vaccines will be required but several lines of investigation have suggested ways in which DNA vaccines may be improved, such as increases in expression, facilitation of DNA targeting or uptake, and enhancement of immune responses.

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Citations

Aug 17, 2000·Springer Seminars in Immunopathology·G J Weiner
Sep 5, 2002·Veterinary Immunology and Immunopathology·G L OshopR A Heckert
Sep 25, 2003·Vaccine·Su WangMichael J Caulfield
Jan 13, 1998·Current Opinion in Biotechnology·P A PattenW P Stemmer
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Oct 9, 1998·Viral Immunology·L Kucerova
Apr 25, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·B BalasaN Sarvetnick
Jan 20, 2006·FEMS Immunology and Medical Microbiology·Hoorieh SoleimanjahiKeivan Zandi
Oct 2, 2014·Expert Review of Vaccines·Karl Ljungberg, Peter Liljeström

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