Toward tissue-engineering of nasal cartilages

Acta Biomaterialia
Laura LaverniaKyriacos Athanasiou

Abstract

Nasal cartilage pathologies are common; for example, up to 80% of people are afflicted by deviated nasal septum conditions. Because cartilage provides the supportive framework of the nose, afflicted patients suffer low quality of life. To correct pathologies, graft cartilage is often required. Grafts are currently sourced from the patient's septum, ear, or rib. However, their use yields donor site morbidity and is limited by tissue quantity and quality. Additionally, rhinoplasty revision rates exceed 15%, exacerbating the shortage of graft cartilage. Alternative grafts, such as irradiated allogeneic rib cartilage, are associated with complications. Tissue-engineered neocartilage holds promise to address the limitations of current grafts. The engineering design process may be used to create suitable graft tissues. This process begins by identifying the surgeon's needs. Second, nasal cartilages' properties must be understood to define engineering design criteria. Limited investigations have examined nasal cartilage properties; numerous additional studies need to be performed to examine topographical variations, for example. Third, tissue-engineering processes must be applied to achieve the engineering design criteria. Within the ...Continue Reading

Citations

Jan 16, 2020·Polymers·Aureliano FertuzinhosNuno Dourado
Sep 17, 2019·Connective Tissue Research·Roberto Di GesùRiccardo Gottardi
Mar 11, 2020·Advanced Science·Yasamin A JodatSu Ryon Shin
Jul 29, 2020·International Journal of Oral Science·Bing Shi, Hanyao Huang
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Pranidhi BaddamDaniel Graf
Jul 28, 2021·Aesthetic Plastic Surgery·Yanyan CaoYonghuan Zhen
Sep 23, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Abbas ShokriLobat Tayebi

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