Toward true closed-loop neuromodulation: artifact-free recording during stimulation

Current Opinion in Neurobiology
Andy ZhouRikky Muller

Abstract

Closed-loop and responsive neuromodulation systems improve open-loop neurostimulation by responding directly to measured neural activity and providing adaptive, on-demand therapy. To be effective, these systems must be able to simultaneously record and stimulate neural activity, a task made difficult by persistent stimulation artifacts that distort and obscure underlying biomarkers. To enable simultaneous stimulation and recording, several techniques have been proposed. These techniques involve artifact-preventing system configurations, resilient recording front-ends, and back-end signal processing for removing recorded artifacts. Co-designing and integrating these artifact cancellation techniques will be key to enabling neuromodulation systems to stimulate and record at the same time. Here, we review the state-of-the-art for these techniques and their role in achieving artifact-free neuromodulation.

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Citations

Feb 7, 2020·Journal of Stroke·Shi-Chun BaoRaymond Kai-Yu Tong
Feb 28, 2020·Journal of Neural Engineering·D J CaldwellB W Brunton
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Jan 8, 2022·Biosensors & Bioelectronics·Jason P WrightTimir Datta-Chaudhuri

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