Toward tubulysin: gram-scale synthesis of tubuvaline-tubuphenylalanine fragment

The Journal of Organic Chemistry
Srivari ChandrasekharMitta Kavitha

Abstract

A practical and stereoselective synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin is achieved involving the opening of aziridine, crucial MacMillan alpha-hydroxylation on both fragments, and an epoxide-opening reaction.

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Citations

May 3, 2011·Journal of the American Chemical Society·Orlando PandoLudger A Wessjohann
Oct 22, 2011·Journal of the American Chemical Society·Wenbo Pei, Isaac J Krauss
Dec 22, 2012·Journal of the American Chemical Society·Hongkun LinIsaac J Krauss
Oct 6, 2012·The Journal of Organic Chemistry·Dominic Becker, Uli Kazmaier
Aug 25, 2010·Chemistry : a European Journal·Taku ShibueOsamu Tamura
Jul 10, 2020·Organic & Biomolecular Chemistry·Bohua LongZhengzhi Wu
Apr 12, 2013·Chemistry, an Asian Journal·Xiu-dong YangYue Chen
Apr 24, 2014·The Journal of Organic Chemistry·Gabrielle J DugasIsaac J Krauss

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