Toward Understanding in Vivo Sequestration of Nanoparticles at the Molecular Level

ACS Nano
Bohan YinChung Hang Jonathan Choi

Abstract

A longstanding and widely accepted bottleneck in the targeted delivery of intravenously injected nanoparticles lies in their clearance by macrophages in the liver and spleen. In this Perspective, we call for deeper understanding of the critical role of endothelial cells in the sequestration of nanoparticles in vivo. In this issue of ACS Nano, Campbell et al. used a combination of real-time imaging and genome-editing methods to demonstrate that stabilin-2 is an important receptor for removing anionic liposomes from blood circulation in a zebrafish model. Such mechanistic insights at the molecular level will provide a more holistic picture of the in vivo sequestration of administered nanoparticles beyond the cellular level and pose valuable design considerations for redistributing nanoparticles in vivo.

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Citations

Aug 16, 2019·Nanomedicine·Maria Antonietta RizzutoDavide Prosperi
Nov 11, 2020·Biochemistry·Lok Wai Cola HoChung Hang Jonathan Choi
May 7, 2019·Accounts of Chemical Research·Lok Wai Cola HoChung Hang Jonathan Choi
Jun 8, 2018·ACS Nano·Thomas BonnardChristoph E Hagemeyer
Dec 6, 2018·ACS Applied Materials & Interfaces·Lei ZhangChung Hang Jonathan Choi

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